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Recombinant Human Collagen, Type I, Alpha 1

Cat.No. : COL1A1-1206H
Product Overview : Recombinant HumanCOL1A1 was expressed in Pichia pastoris.
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  • Gene Information
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Cat. No. : COL1A1-1206H
Description : Collagen, type I,alpha 1, also known as COL1A1, is a human gene that encodes the majorcomponent of type I collagen, the fibrillar collagen found in most connectivetissues, including cartilage. Collagen is a protein that strengthens andsupports many tissues in the body, including cartilage, bone, tendon, skin and thewhite part of the eye (sclera). The COL1A1 gene produces a component of typeI collagen, called the pro-alpha1(I) chain. This chain combines with anotherpro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by theCOL1A2 gene) to make a molecule of type I procollagen. These triple-stranded,rope-like procollagen molecules must be processed by enzymes outside thecell. Once these molecules are processed, they arrange themselves into long,thin fibrils that cross-link to one another in the spaces around cells. Thecross-links result in the formation of very strong mature type I collagenfibers.
Source : Pichia pastoris
Species : Human
Form : Liquid, sterilefiltered in 0.01 M HCl.
Concentration : 2.7 mg/ml
Purity : > 99.0% asdetermined by SDS-PAGE
Storage : Store at 2-4°C.
OfficialSymbol : COL1A1
Gene Name : COL1A1 collagen, type I, alpha 1 [ Homosapiens ]
Synonyms : COL1A1; collagen,type I, alpha 1; OI4; collagen alpha-1 (I) chain; Alpha-1 type I collagen;pro-alpha-1 collagen type 1; collagen alpha 1(I) chain type I; collagen ofskin, tendon and bone, alpha-1 chain
Gene ID : 1277
mRNA Refseq : NM_000088
Protein Refseq : NP_000079
MIM : 120150
UniProt ID : P02452
Chromosome Location : 17q21.33
Pathway : Amoebiasis; Cellsurface interactions at the vascular wall; Collagen adhesion via Gp IV;ECM-receptor interaction; Focal adhesion; Inflammatory Response Pathway;Platelet Activation; vWF interaction with collagen; Hemostasis; IL4-mediatedsignaling events; Inflammatory Response Pathway; Integrin cell surfaceinteractions; NCAM signaling for neurite out-growth; Osteoblast Signaling;Platelet Adhesion to exposed collagen
Function : extracellular matrixstructural constituent; identical protein binding; platelet-derived growthfactor binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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