"CDC42BPA" Related Products

Recombinant Human CDC42 Binding Protein Kinase Alpha (DMPK-like), His-tagged

Cat. No.: CDC42BPA-368H
Product Overview: Recombinanthuman CDC42BPA, catalytic domain (amino acids 1-473) with His Tag.
Description: Theprotein encoded by this gene is a member of the Serine/Threonine proteinkinase family. This kinase contains multiple functional domains. Its kinasedomain is highly similar to that of the myotonic dystrophy protein kinase(DMPK). This kinase also contains a Rac interactive binding (CRIB) domain,and has been shown to bind CDC42. It may function as a CDC42 downstreameffector mediating CDC42 induced peripheral actin formation, and promotingcytoskeletal reorganization. Multiple alternatively spliced transcriptvariants have been described, and the full-length nature of two of them hasbeen reported.
Source: Insectcells
Species: Human
Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
Molecular Weight: 58.7 kDa
Purity: ≥ 90% asdetermined by a Coomassie blue-stained SDS-PAGE gel.
Specific Activity: 179 nmoleof phosphate transferred to S6 peptide substrate (AKRRRLSSLRA) per minute permg of total protein at 30°C. Activity determined at a final protein concentrationof 3.33 ug/ml.
Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: CDC42BPA
Gene Name: CDC42BPACDC42 binding protein kinase alpha (DMPK-like) [ Homo sapiens ]
Synonyms: CDC42BPA;CDC42 binding protein kinase alpha (DMPK-like); MRCK; MRCKA; PK428;FLJ23347; KIAA0451; DKFZp686L1738; DKFZp686P1738; CDC42-bindingprotein kinase alpha (DMPK-like); OTTHUMP00000035727; OTTHUMP00000035728; OTTHUMP00000035729;OTTHUMP00000035730; OTTHUMP00000035731; OTTHUMP00000035732; OTTHUMP00000035733;Serine/threonine-proteinkinase MRCK alpha; EC; CDC42-binding protein kinasealpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinasealpha; ser-thr protein kinaserelated to the myotonic dystrophy protein kinase
Gene ID: 8476
mRNA Refseq: NM_003607
Protein Refseq: NP_003598
MIM: 603412
UniProt ID: Q5VT25
Chromosome Location: 1q42.11
Pathway: CDC42 signalingevents
Function: protein binding; ATPbinding; identical protein binding; magnesium ion binding; nucleotidebinding; protein serine/threoninekinase activity; small GTPase regulator activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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