Recombinant Human CDC42 Binding Protein Kinase Alpha (DMPK-like), His-tagged


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Recombinant Human CDC42 Binding Protein Kinase Alpha (DMPK-like), His-tagged

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Cat. No. : CDC42BPA-368H
Product Overview : Recombinanthuman CDC42BPA, catalytic domain (amino acids 1-473) with His Tag.
Description : Theprotein encoded by this gene is a member of the Serine/Threonine proteinkinase family. This kinase contains multiple functional domains. Its kinasedomain is highly similar to that of the myotonic dystrophy protein kinase(DMPK). This kinase also contains a Rac interactive binding (CRIB) domain,and has been shown to bind CDC42. It may function as a CDC42 downstreameffector mediating CDC42 induced peripheral actin formation, and promotingcytoskeletal reorganization. Multiple alternatively spliced transcriptvariants have been described, and the full-length nature of two of them hasbeen reported.
Source : Insectcells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
Molecular Weight : 58.7 kDa
Purity : ≥ 90% asdetermined by a Coomassie blue-stained SDS-PAGE gel.
Specific Activity : 179 nmoleof phosphate transferred to S6 peptide substrate (AKRRRLSSLRA) per minute permg of total protein at 30°C. Activity determined at a final protein concentrationof 3.33 ug/ml.
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : CDC42BPA
Gene Name : CDC42BPACDC42 binding protein kinase alpha (DMPK-like) [ Homo sapiens ]
Synonyms : CDC42BPA;CDC42 binding protein kinase alpha (DMPK-like); MRCK; MRCKA; PK428;FLJ23347; KIAA0451; DKFZp686L1738; DKFZp686P1738; CDC42-bindingprotein kinase alpha (DMPK-like); OTTHUMP00000035727; OTTHUMP00000035728; OTTHUMP00000035729;OTTHUMP00000035730; OTTHUMP00000035731; OTTHUMP00000035732; OTTHUMP00000035733;Serine/threonine-proteinkinase MRCK alpha; EC; CDC42-binding protein kinasealpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinasealpha; ser-thr protein kinaserelated to the myotonic dystrophy protein kinase
Gene ID : 8476
mRNA Refseq : NM_003607
Protein Refseq : NP_003598
MIM : 603412
UniProt ID : Q5VT25
Chromosome Location : 1q42.11
Pathway : CDC42 signalingevents
Function : protein binding; ATPbinding; identical protein binding; magnesium ion binding; nucleotidebinding; protein serine/threoninekinase activity; small GTPase regulator activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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