Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog B

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Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog B

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Cat. No. : FOSB-1230H
Product Overview : FOSB encodes a nuclear protein of 338amino acids which has 70% homology with c-Fos, exhibits similar kinetics ofexpression as c-Fos and forms heterodimers with both c-Jun and Jun B whichbind to TRE DNA response elements. Functional homologs of c-Fos and FOSBinclude Fra-1 and Fra-2 genes.
Description : FOSBis a protein that, in humans, is encoded by the FOSB gene. The Fos genefamily consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encodeleucine zipper proteins that can dimerize with proteins of the JUN family,thereby forming the transcription factor complex AP-1. As such, the FOSproteins have been implicated as regulators of cell proliferation,differentiation, and transformation.
Source : E. coli
Species : Human
Form : Recombinant Human FOSB protein(a.a.113-151) at 100 μg/ml in 50 mM Tris-Acetate + pH7.5 + 1 Mm EDTA +20%Glycerol.
Application : ELISA; Inhibition Assays; WesternBlotting
Storage : Store vial at -20°C to -80°C. Whenstored at the recommended temperature, this protein is stable for 12 months.Please avoid freeze-thaw cycles.
OfficialSymbol : FOSB
Gene Name : FOSB FBJmurine osteosarcoma viral oncogene homolog B [ Homo sapiens ]
Synonyms : FOSB; FBJ murine osteosarcoma viraloncogene homolog B; AP-1; G0S3; GOS3; GOSB; MGC42291;DKFZp686C0818; activator protein 1; oncogene FOS-B; protein fosB; G0/G1switch regulatory protein 3
Gene ID : 2354
mRNA Refseq : NM_001114171
Protein Refseq : NP_001107643
MIM : 164772
UniProt ID : P53539
Chromosome Location : 19q13.3
Pathway : Osteoclast differentiation; TGF-betaReceptor Signaling Pathway
Function : protein dimerization activity; sequence-specific DNA binding;transcription factor activity; sequence-specific DNA binding transcriptionfactor activity; DNA binding

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