Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog B

• Cat.No.: FOSB-1230H
• Product Overview: FOSB encodes a nuclear protein of 338amino acids which has 70% homology with c-Fos, exhibits similar kinetics ofexpression as c-Fos and forms heterodimers with both c-Jun and Jun B whichbind to TRE DNA response elements. Functional homologs of c-Fos and FOSBinclude Fra-1 and Fra-2 genes.

Specification

• Cat. No.: FOSB-1230H
• Description: FOSBis a protein that, in humans, is encoded by the FOSB gene. The Fos genefamily consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encodeleucine zipper proteins that can dimerize with proteins of the JUN family,thereby forming the transcription factor complex AP-1. As such, the FOSproteins have been implicated as regulators of cell proliferation,differentiation, and transformation.
• Source: E. coli
• Species: Human
• Form: Recombinant Human FOSB protein(a.a.113-151) at 100 μg/ml in 50 mM Tris-Acetate + pH7.5 + 1 Mm EDTA +20%Glycerol.
• Application: ELISA; Inhibition Assays; WesternBlotting
• Storage: Store vial at -20°C to -80°C. Whenstored at the recommended temperature, this protein is stable for 12 months.Please avoid freeze-thaw cycles.
• OfficialSymbol: FOSB

Gene Information

• Gene Name: FOSB FBJmurine osteosarcoma viral oncogene homolog B [ Homo sapiens ]
• Synonyms: FOSB; FBJ murine osteosarcoma viraloncogene homolog B; AP-1; G0S3; GOS3; GOSB; MGC42291;DKFZp686C0818; activator protein 1; oncogene FOS-B; protein fosB; G0/G1switch regulatory protein 3
• Gene ID: 2354
• mRNA Refseq: NM_001114171
• Protein Refseq: NP_001107643
• MIM: 164772
• UniProt ID: P53539
• Chromosome Location: 19q13.3
• Pathway: Osteoclast differentiation; TGF-betaReceptor Signaling Pathway
• Function: protein dimerization activity; sequence-specific DNA binding;transcription factor activity; sequence-specific DNA binding transcriptionfactor activity; DNA binding