Recombinant Human Fibroblast Growth Factor 7, His-tagged FGF7-682H

Recombinant Human Fibroblast Growth Factor 7, His-tagged


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Recombinant Human Fibroblast Growth Factor 7, His-tagged

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Cat. No. : FGF7-682H
Product Overview : Recombinant human FGF7contains 164 amino acids and a 16 aa His-tag. Total length is 180 aa.
Description : The protein encoded bythis gene is a member of the fibroblast growth factor (FGF) family. FGFfamily members possess broad mitogenic and cell survival activities, and areinvolved in a variety of biological processes, including embryonicdevelopment, cell growth, morphogenesis, tissue repair, tumor growth andinvasion. This protein is a potent epithelial cell-specific growth factor,whose mitogenic activity is predominantly exhibited in keratinocytes but notin fibroblasts and endothelial cells.
Source : Hordeum vulgare(barley grain)
Species : Human
Form : Lyophilized from a0.2 µm sterile filtered solution of PBS, pH 7.2.
Molecular Weight : Predicted MW 21.2kDa including his-tag. The glycosylated recombinant protein migrates with anapparent MW 30 kDa in SDS-PAGE.
Purity : > 98% by SDS-PAGE.Purified product carries no pyrogenic or pro-inflammatory contaminants, asassayed with monocyte activation test using custom human Multiplex CytokineAssay measuring IL-6, TNF-alpha and IL-1beta induction.
Endotoxin Level : < 0.005 ng perµg of product (0.05 EU/µg) as measured by turbidimetric kinetic assay.
Biological Activity : Bioactivity isassayed by measuring the dose dependent effect of human FGF7 on proliferationof mouse BaF3. The ED50 for a typical batch of recombinant human FGF7is 0.20 ng/ml.
Specific Activity : 5.0 x 106U/mg
Cross-Reactivity : Considerablespecies cross-reactivity, including with mouse, monkey, and pig cells.
Reconstitution : Centrifuge vialprior to opening. First addsterile distilled water to the vial to fully solubilize the protein to aconcentration not less than 100 µg/ml. After complete solubilization of theprotein, it can be further diluted to other aqueous solutions.
Storage : The lyophilizedprotein, though stable at room temperature for two weeks, is best stored at-20°C. Reconstituted protein should be used immediately or stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : FGF7
Gene Name : FGF7 fibroblast growth factor 7[ Homo sapiens ]
Synonyms : FGF7; fibroblastgrowth factor 7; KGF; HBGF-7;keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growthfactor 7
Gene ID : 2252
mRNA Refseq : NM_002009
Protein Refseq : NP_002000
MIM : 148180
UniProt ID : P21781
Chromosome Location : 15q15-q21.1
Pathway : Downstream signalingof activated FGFR; FGFR ligand binding and activation; FGFR2 ligand bindingand activation; FGFR2b ligand binding and activation; FRS2-mediated cascade; Glypican3 network; IRS-mediated signalling; IRS-related events; Insulin receptorsignalling cascade; MAPK signaling pathway; Melanoma; Negative regulation ofFGFR signaling; PI-3K cascade; Pathways in cancer; Phospholipase C-mediatedcascade; SHC-mediated cascade
Function : chemoattractant activity;growth factor activity; heparin binding; type 2 fibroblast growth factorreceptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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