Cat. No. :	FGFR2-5418H
Product Overview :	Recombinant humanFGFR2 cytoplasmic domain (amino acids 403-822), His-tagged. No specialmeasures were taken to activate this kinase.
Description :	This protein functions as amodifier of endothelial cell migration and proliferation, as well as anangiogenic factor. It acts as a mitogen for a variety of mesoderm- andneuroectoderm-derived cells in vitro, thus is thought to be involved inorganogenesis. Three alternatively spliced variants encoding differentisoforms have been described. The heparin-binding growth factors areangiogenic agents in vivo and are potent mitogens for a variety of cell typesin vitro. There are differences in the tissue distribution and concentrationof these 2 growth factors.
Source :	Insect cells
Species :	Human
MolecularWeight :	52.1 kDa
Purity :	≥ 90% as determinedby SDS-PAGE analysis
Specific Activity :	2700nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute permg oftotalprotein at 30°C. Activity determined at a final protein concentration of 1μg/ml.
Storage :	Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol :	FGFR2

Gene Name :	FGFR2 fibroblast growth factorreceptor 2 [ Homo sapiens ]
Synonyms :	FGFR2; fibroblast growth factorreceptor 2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332;K-SAM; FLJ98662; FGFR2; KSAR; FGFR-2; KSAM; OTTHUMP00000020621;OTTHUMP00000020629; BEK fibroblast growth factor receptor; CD332 antigen; FGFreceptor; Jackson-Weiss syndrome; Keratinocyte growth factor receptor 2;bacteria-expressed kinase; craniofacial dysostosis 1; fibroblast growthfactor receptor 2; hydroxyaryl-protein kinase; keratinocyte growth factorreceptor; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4
Gene ID :	2263
mRNA Refseq :	NM_000141
Protein Refseq :	NP_000132
MIM :	176943
UniProt ID :	P21802
Chromosome Location :	10q26
Pathway :	Angiogenesis;Downstream signaling of activated FGFR; Endocytosis; FGF signaling pathway;FGFR ligand binding and activation; FGFR2 ligand binding and activation;FRS2-mediated cascade; IRS-mediated signalling; Insulin receptor signallingcascade; MAPK signaling pathway; Negative regulation of FGFR signaling; PI-3Kcascade; Pathways in cancer; Regulation of Actin Cytoskeleton; SHC-mediatedcascade
Function :	ATP binding; fibroblast growthfactor receptor activity; heparin binding; nucleotide binding; proteinbinding; receptor activity; transferase activity

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