"EPHA3" Related Products


Recombinant Human EPH Receptor A3, His-tagged

Cat. No.: EPHA3-1880H
Product Overview: Recombinant humanEPHA3 cytoplasmic domain (aa 569-983) with His tag. Activated in vitro viaauto-phosphorylation.
Description: EPHA3 (ephrin type-Areceptor 3) is a protein that inhumans is encoded by the EPHA3 gene. This gene belongs to the ephrin receptorsubfamily of the protein-tyrosine kinase family. EPH and EPH-related receptorshave been implicated in mediating developmental events, particularly in thenervous system. Receptors in the EPH subfamily typically have a single kinasedomain and an extracellular region containing a Cys-rich domain and 2fibronectin type III repeats. The ephrin receptors are divided into 2 groupsbased on the similarity of their extracellular domain sequences and theiraffinities for binding ephrin-A and ephrin-B ligands.
Source: E. coli
Species: Human
Form: Liquid in 20 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol.
Molecular Weight: 50.8 kDa
Purity: ≥ 90% as determinedby SDS-PAGE analysis.
Specific Activity: 1000 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 1 μg/ml.
Concentration: 0.4 mg/ml
Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: EPHA3
Gene Name: EPHA3 EPH receptor A3 [ Homosapiens ]
Synonyms: EPHA3; EPH receptorA3; EK4;ETK; HEK; ETK1; HEK4; TYRO4; ephrin type-A receptor 3; EPH-like kinase 4;OTTHUMP00000213903; OTTHUMP00000213904; OTTHUMP00000213905; human embryokinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase;tyrosine-protein kinase receptor ETK1
Gene ID: 2042
mRNA Refseq: NM_005233
Protein Refseq: NP_005224
MIM: 179611
UniProt ID: P29320
Chromosome Location: 3p11.2
Pathway: Axon guidance; EPHAforward signaling; EphrinA-EPHA pathway
Function: ATP binding;GPI-linked ephrin receptor activity; nucleotide binding; protein binding;receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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