Native Human Coagulation Factor XIII, A1 Polypeptide

• Cat.No.: F13A1-1881H
• Product Overview: Native human F13A1 wasexpressed in Human plasma.

Specification

• Cat. No.: F13A1-1881H
• Description: F13A1 is a tetramercomposed of two pairs of chains held together by noncovalent bonds. Afteractivation of the zymogen via Thrombin to its active enzyme form, activatedFactor Xllla is responsible for catalyzing the formation of covalent bridgesbetween fibrin units to increase the elasticity of the clot network. Theresulting cross-linked fibrin is very insoluble and resistant to lysis.
• Form: Frozen liquidcontaining 0.05 M Tris-HCI Buffer+0.15 M NaCI+0.001 M EDTA+10 U/mlAprotinin+20% Glycerol, pH 7.5.
• Source: Human plasma
• Molecular Weight: 320 kDa
• Purity: >95% by SDS-PAGEanalysis
• Endotoxin Level: <0.1 ng/ug ofprotein
• Concentration: 5.0 mg/ml
• Storage: Store at -80oC.Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
• Pathways: CommonPathway;Complement and coagulation cascades; Formation of Fibrin Clot (Clotting Cascade); Hemostasis; Plateletactivation; Platelet degranulation;Response to elevated platelet cytosolic Ca2+

Gene Information

• Gene Name: F13A1 coagulation factor XIII,A1 polypeptide [ Homo sapiens ]
• Official Symbol: F13A1
• Synonyms: F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase;FSF, A subunit; OTTHUMP00000015990; coagulation factor XIIIa; transglutaminaseA chain; transglutaminase. Plasma; fibrin stabilizing factor, A subunit; coagulationfactor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase Achain; bA525O21.1 (coagulation factor XIII, A1 polypeptide)
• Gene ID: 2162
• mRNA Refseq: NM_000129
• Protein Refseq: NP_000120
• MIM: 134570
• UniProt ID: P00488
• Chromosome Location: 6p24.2-p23
• Function: metalion binding; protein-glutamine gamma-glutamyltransferase activity;protein-glutamine gamma-glutamyltransferase activity; transferase activity,transferring acyl groups