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Recombinant Rat Plasminogen Activator, Urokinase

Cat. No.: Plau-1297R
Product Overview: RecombinantRat High Molecular Weight two-chain Plau.
Description: Plauisan enzyme that in humans is encoded by the Plau gene. This gene encodes aserine protease involved in degradation of the extracellular matrix andpossibly tumor cell migration and proliferation. A specific polymorphism inthis gene may be associated with late-onset Alzheimer disease and also withdecreased affinity for fibrin-binding. The protein encoded by this geneconverts plasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.
Source: Insect cells
Species: Human
Formulation: Frozen liquid in 0.05M Sodium Acetate+0.1M NaCI+1mM EDTA, pH 5.0.
Molecular Weight: 44.0 kDa
Concentration: 2.0 mg/mL
Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: Plau
Gene Name: Plauplasminogen activator, urokinase [ Rattus norvegicus ]
Synonyms: Plau; plasminogenactivator, urokinase; UPAM; MGC124931; urokinase-typeplasminogen activator; uPA; U-plasminogen activator; Urinary plasminogenactivator, urokinase
Gene ID: 25619
mRNA Refseq: NM_013085
Protein Refseq: NP_037217
UniProt ID: Q3KR76
Chromosome Location: 15p16
Pathway: BloodClotting Cascade; Complement and Coagulation Cascades; Complement andcoagulation cascades; Dissolution of Fibrin Clot; Endochondral Ossification;Hemostasis; Wnt Signaling Pathway; Wnt Signaling Pathway and Pluripotency
Function: kinase activity; peptidase activity; serine-typeendopeptidase activity

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