"Plau" Related Products

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Recombinant Rat Plasminogen Activator, Urokinase

Cat. No. : Plau-1297R
Product Overview : RecombinantRat High Molecular Weight two-chain Plau.
Description : Plauisan enzyme that in humans is encoded by the Plau gene. This gene encodes aserine protease involved in degradation of the extracellular matrix andpossibly tumor cell migration and proliferation. A specific polymorphism inthis gene may be associated with late-onset Alzheimer disease and also withdecreased affinity for fibrin-binding. The protein encoded by this geneconverts plasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.
Source : Insect cells
Species : Human
Formulation : Frozen liquid in 0.05M Sodium Acetate+0.1M NaCI+1mM EDTA, pH 5.0.
Molecular Weight : 44.0 kDa
Concentration : 2.0 mg/mL
Storage : Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : Plau
PDBrendering based on 1c5w. :

Gene Name : Plauplasminogen activator, urokinase [ Rattus norvegicus ]
Synonyms : Plau; plasminogenactivator, urokinase; UPAM; MGC124931; urokinase-typeplasminogen activator; uPA; U-plasminogen activator; Urinary plasminogenactivator, urokinase
Gene ID : 25619
mRNA Refseq : NM_013085
Protein Refseq : NP_037217
UniProt ID : Q3KR76
Chromosome Location : 15p16
Pathway : BloodClotting Cascade; Complement and Coagulation Cascades; Complement andcoagulation cascades; Dissolution of Fibrin Clot; Endochondral Ossification;Hemostasis; Wnt Signaling Pathway; Wnt Signaling Pathway and Pluripotency
Function : kinase activity; peptidase activity; serine-typeendopeptidase activity

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