Recombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase), GST-tagged
Cat.No. : | KDR-5446H |
Product Overview : | Recombinant human KDR(aa 805-1356) has a N-terminal GST Tag and has a MW=87.0 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | KDR-5446H |
Description : | Kinase insertdomain receptor (KDR, a type III receptor tyrosine kinase) also known asvascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor.KDR is the human gene encoding it. KDR has also been designated as CD309(cluster of differentiation 309). KDR is also known as Flk1 (Fetal LiverKinase 1). |
Source : | Baculovirus infectedSf9 Cells |
Species : | Human |
Form : | Liquid containing 25mM Tris-HCL, pH 8.0 + 100 mM NaCl + 0.05% Tween-20 + 50% glycerol + 10 mMreduced glutathione + 3 mM DTT |
Molecular Weight : | 87.0 kDa |
Purity : | >90% asdetermined by SDS-PAGE |
Endotoxin Level : | Less than 0.1 ng/µgof protein |
Biological Activity : | One unit is definedas the amount of enzyme that will transfer 1 pmol phosphate to Tyr substrateper minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2,3 mM MnCl2, 1 mM DTT, 3 µM Na-orthovanadate, 0.5 mM ATP, 30 µg/ml Poly(Glu:Tyr) 4:1 substrate, 1 µg/ml recombinant VEGFR2. |
Applications : | Useful for thestudy of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | Stable for more than6 months when stored at -80°C. |
OfficialSymbol : | KDR |
Gene Name : | KDR kinase insert domainreceptor (a type III receptor tyrosine kinase) [ Homo sapiens ] |
Synonyms : | KDR; kinase insertdomain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR;VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2;OTTHUMP00000158928; fetal liver kinase 1; fetal liver kinase-1;protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factorreceptor; EC 2.7.10; EC 2.7.10.1 |
Gene ID : | 3791 |
mRNA Refseq : | NM_002253 |
Protein Refseq : | NP_002244 |
MIM : | 191306 |
UniProt ID : | P35968 |
Chromosome Location : | 4q11-q12 |
Pathway : | Angiogenesis;Cytokine-cytokine receptor interaction; Endocytosis; Focal Adhesion;HIF-2-alpha transcription factor network; Id Signaling Pathway; Integrins inangiogenesis; Neurophilin interactions with VEGF and VEGFR; Notch-mediatedHES/HEY network; S1P1 pathway; Signal Transduction; Signaling events mediatedby VEGFR1 and VEGFR2; VEGF binds to VEGFR leading to receptor dimerization;VEGF ligand-receptor interactions; VEGF signaling pathway |
Function : | ATP binding; Hsp90protein binding; growth factor binding; integrin binding; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity;receptor signaling protein tyrosine kinase activity; transmembrane receptorprotein tyrosine kinase activity; vascular endothelial growthfactor-activated receptor activity |
Products Types
◆ Lysates | ||
KDR-1520MCL | Recombinant Mouse KDR cell lysate | +Inquiry |
KDR-417HCL | Recombinant Human KDR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1609 | KDR Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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