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Recombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase), GST-tagged

Cat. No. : KDR-5446H
Product Overview : Recombinant human KDR(aa 805-1356) has a N-terminal GST Tag and has a MW=87.0 kDa.
Description : Kinase insertdomain receptor (KDR, a type III receptor tyrosine kinase) also known asvascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor.KDR is the human gene encoding it. KDR has also been designated as CD309(cluster of differentiation 309). KDR is also known as Flk1 (Fetal LiverKinase 1).
Source : Baculovirus infectedSf9 Cells
Species : Human
Form : Liquid containing 25mM Tris-HCL, pH 8.0 + 100 mM NaCl + 0.05% Tween-20 + 50% glycerol + 10 mMreduced glutathione + 3 mM DTT
Molecular Weight : 87.0 kDa
Purity : >90% asdetermined by SDS-PAGE
Endotoxin Level : Less than 0.1 ng/µgof protein
Biological Activity : One unit is definedas the amount of enzyme that will transfer 1 pmol phosphate to Tyr substrateper minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2,3 mM MnCl2, 1 mM DTT, 3 µM Na-orthovanadate, 0.5 mM ATP, 30 µg/ml Poly(Glu:Tyr) 4:1 substrate, 1 µg/ml recombinant VEGFR2.
Applications : Useful for thestudy of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : Stable for more than6 months when stored at -80°C.
OfficialSymbol : KDR
Rendering of 1VR2. :

Gene Name : KDR kinase insert domainreceptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
Synonyms : KDR; kinase insertdomain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR;VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2;OTTHUMP00000158928; fetal liver kinase 1; fetal liver kinase-1;protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factorreceptor; EC 2.7.10; EC 2.7.10.1
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
UniProt ID : P35968
Chromosome Location : 4q11-q12
Pathway : Angiogenesis;Cytokine-cytokine receptor interaction; Endocytosis; Focal Adhesion;HIF-2-alpha transcription factor network; Id Signaling Pathway; Integrins inangiogenesis; Neurophilin interactions with VEGF and VEGFR; Notch-mediatedHES/HEY network; S1P1 pathway; Signal Transduction; Signaling events mediatedby VEGFR1 and VEGFR2; VEGF binds to VEGFR leading to receptor dimerization;VEGF ligand-receptor interactions; VEGF signaling pathway
Function : ATP binding; Hsp90protein binding; growth factor binding; integrin binding; nucleotide binding;protein binding; protein tyrosine kinase activity; receptor activity;receptor signaling protein tyrosine kinase activity; transmembrane receptorprotein tyrosine kinase activity; vascular endothelial growthfactor-activated receptor activity

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