Recombinant Human Plasminogen Activator, Tissue
Cat.No. : | PLAT-1292H |
Product Overview : | Recombinant Human PLATNon-Cleavable, and the addition of a R257E mutation generates human PLAT thatis 100% single chain and resistant to cleavage by plasmin. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PLAT-1292H |
Description : | Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma. |
Source : | Insect cells |
Species : | Human |
Form : | Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4 |
Molecular Weight : | 70.0 kDa |
Concentration : | 2.0 mg/ml |
Storage : | Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | PLAT |
Gene Name : | PLAT plasminogen activator,tissue [ Homo sapiens ] |
Synonyms : | PLAT; plasminogenactivator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogenactivator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784;OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787;OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissuetype; tissue plasminogen activator (t-PA); EC 3.4.21.68 |
Gene ID : | 5327 |
mRNA Refseq : | NM_000930 |
Protein Refseq : | NP_000921 |
MIM : | 173370 |
UniProt ID : | P00750 |
Chromosome Location : | 8p12 |
Pathway : | Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Selenium Pathway; Senescence and Autophagy;Signal Transduction; Signaling by PDGF; amb2 Integrin signaling |
Function : | peptidase activity;protein binding; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
PLAT-4154R | Recombinant Rat PLAT Protein, His (Fc)-Avi-tagged | +Inquiry |
Plat-5462R | Recombinant Rat Plasminogen Activator, Tissue | +Inquiry |
PLAT-5461H | Recombinant Human Plasminogen Activator, Tissue | +Inquiry |
PLAT-72H | Active Recombinant Human PLAT protein(Ile311-Pro562), hFc-tagged | +Inquiry |
PLAT-1870H | Recombinant Human PLAT Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
PLAT-29690TH | Native Human Human SERPINE1 | +Inquiry |
PLAT-30946TH | Native Human PLAT | +Inquiry |
PLAT-30920TH | Native Human PLAT | +Inquiry |
◆ Lysates | ||
PLAT-1498MCL | Recombinant Mouse PLAT cell lysate | +Inquiry |
PLAT-2833HCL | Recombinant Human PLAT cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0701 | PLAT (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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