||Recombinant Human PLATNon-Cleavable, and the addition of a R257E mutation generates human PLAT thatis 100% single chain and resistant to cleavage by plasmin.
||Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma.
||Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4
||Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.