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Recombinant Human Plasminogen Activator, Tissue

Cat. No.: PLAT-1292H
Product Overview: Recombinant Human PLATNon-Cleavable, and the addition of a R257E mutation generates human PLAT thatis 100% single chain and resistant to cleavage by plasmin.
Description: Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma.
Source: Insect cells
Species: Human
Form: Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4
Molecular Weight: 70.0 kDa
Concentration: 2.0 mg/ml
Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: PLAT
Gene Name: PLAT plasminogen activator,tissue [ Homo sapiens ]
Synonyms: PLAT; plasminogenactivator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogenactivator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784;OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787;OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissuetype; tissue plasminogen activator (t-PA); EC 3.4.21.68
Gene ID: 5327
mRNA Refseq: NM_000930
Protein Refseq: NP_000921
MIM: 173370
UniProt ID: P00750
Chromosome Location: 8p12
Pathway: Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Selenium Pathway; Senescence and Autophagy;Signal Transduction; Signaling by PDGF; amb2 Integrin signaling
Function: peptidase activity;protein binding; serine-type endopeptidase activity

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