Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 3, GST-tagged


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Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 3, GST-tagged

NR1I3 Related Products

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Cat. No. : NR1I3-1277H
Product Overview : Recombinant human NR1I3, Ligand Binding Domain with GST tag,containing amino acids 101-348.
Description : NR1I3 was identified as amember of the orphan nuclear hormone receptor family in 1994. Althoughconstitutively acitve, it can be further activated by phenobarbitol-likecompounds, the most potent being the synthetic compound TCPOBOP. Uponactivation, NR1I3 regulates the xenobiotic drug metabolizing enzymes,cytochrome P450s.
Source : E. coli
Species : Human
Form : Liquid in 20 mMTris-Cl + 25% glycerol + 100 mM KCl + 1 mM DTT + 0.2 mM EDTA.
Purity : > 95%as determined by SDS-PAGE analysis
Applications : In vitro transcriptionassays; DNA-protein interaction assays; Protein-protein interaction assays.
storage : Stablefor 1 year in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : NR1I3
Pathways : Gene Expression; Generic TranscriptionPathway; Glucocorticoid receptor regulatory network; Nuclear Receptortranscription pathway; Nuclear Receptors; Nuclear receptors in lipidmetabolism and toxicity
PDBrendering based on 1xv9. :

Gene Name : NR1I3 nuclear receptor subfamily1, group I, member 3 [ Homo sapiens ]
Synonyms : NR1I3; nuclear receptorsubfamily 1, group I, member 3; CAR; CAR1; MB67; MGC97144; MGC97209;MGC150433; constitutive androstane receptor; OTTHUMP00000032246; constitutiveactive receptor; orphan nuclear hormone receptor; constitutive activator ofretinoid response; Nuclear receptor subfamily 1 group I member 3; Orphannuclear receptor MB67; OTTHUMP00000032245
Gene ID : 9970
mRNA Refseq : NM_001077469
Protein Refseq : NP_001070937
MIM : 603881
UniProt ID : Q14994
Chromosome Location : 1q23.3
Function : DNA binding; androgen receptor activity; ligand-dependentnuclear receptor activity; metal ion binding; receptor activity; sequence-specificDNA binding; sequence-specific DNA binding transcription factor activity; steroidhormone receptor activity; thyroid hormone receptor activity; transcriptioncoactivator activity; zinc ion binding

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