"NRG1" Related Products

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Recombinant Human Neuregulin 1, HQ-tagged

Cat. No.: NRG1-1280H
Product Overview: Recombinant humanNRG1 contains 62 amino acids and a 16 aa HQ tag. Total length is 78 aa.
Description: NRG1 is asignaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac musclecells, playing an important role in heart structure and function throughinducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocytedifferentiation. Research on molecular level discovered that recombinantneuregulin could make disturbed myocardial cell structure into order andstrengthen the connection between myocardial cells by intercalated discsre-organization.
Source: Hordeum vulgare(barley grain). Barley grain"s proteolytic activity is almost 50 times less thanE. coli or mammalian cells. Barley seed has no human or animal viralcontaminants, which is ideal for cell culture and in vitro and in vivobiological experiments.
Species: Human
Form: Lyophilized from a0.2 umg sterile filtered solution of PBS, pH 7.2.
Purity: > 98%by SDS-PAGE. Purified product carries no pyrogenic or pro-inflammatorycontaminants, as assayed with monocyte activation test using custom humanMultiplex Cytokine Assay measuring IL-6, TNF-alpha and IL-1beta induction.
Endotoxin Level: < 0.005ng per ug of product (0.05 EU/ug) as measured by turbidimetric kinetic assay.
Biological Activity: Determinedby dose-dependent cell proliferation assay for MCF-7 cells. ED50for a typical batch of NRG1 lies in the range of 0.9-1.3 ng/ml.
Specific Activity: 1.11 x 106units/mg
Reconstitution: Centrifugevial prior to opening. First add sterile distilled water to thevial to fully solubilize the protein to a concentration not less than 100 ug/ml.After complete solubilization of the protein, it can be further diluted toother aqueous solutions.
storage: Thelyophilized protein, though stable at room temperature for two weeks, is beststored at -20°C.Reconstituted protein should be used immediately or stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: NRG1
Pathways: ErbB signaling pathway; Glypican1 network; MicroRNAs in cardiomyocyte hypertrophy
Gene Name: NRG1 neuregulin 1 [ Homosapiens ]
Synonyms: NRG1; neuregulin 1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF;Neuregulin-1, sensory and motor neuron-derived factor isoform;Pro-neuregulin-1, membrane-bound isoform precursor; neu differentiationfactor; neuregulin 1; sensory and motor neuron derived factor; Pro-NRG1;glial growth factor; heregulin, alpha (45kD, ERBB2 p185-activator)
Gene ID: 3084
mRNA Refseq: NM_004495
Protein Refseq: NP_004486
MIM: 142445
UniProt ID: Q15491
Chromosome Location: 8p12
Function: growth factoractivity; receptor tyrosine kinase binding; Molecular function; ErbB-3 classreceptor binding; transcription cofactor activity; transmembrane receptorprotein tyrosine kinase activator activity

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