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TNFRII-Fc-IL 1RA

Cat.No. : TFI-P1007H
Product Overview : Duplexprotein drug that TFI was fused with tumor necrosis factor receptor 2 andinterleukin-1 receptor antagonist by Fc fragment of human IgG protein.
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Cat. No. : TFI-P1007H
Description : Therole of TNF in inflammatory diseases has been well established. TNFRII fusedto human IgG1 Fc fragment (trade name Enbrel) has been used for treatingcertain TNF-dependent disorders such as rheumatoid arthritis and psoriasis.Since TNF alpha and IL-1 are two major players in inflammatory diseases, afusion or chimeric of a TNF antagonist and an IL-1ra or its functionalequivalent can be used to block both TNF alpha and IL-1 pathways, andtherefore can be used to treat acute and chronic inflammation-related diseasesmore effectively than each individually. IL-1ra binds to IL-1 receptors anddirects the fused therapeutic agent to IL-1 receptor-rich inflammation site.It also neutralizes IL-1 activity. The fusion of IL-1ra and any of theseproteins can be used in treating inflammation, asthma, andangiogenesis-related disorders or endothelial cell proliferation-relateddisorders.
Source : ChineseHamster Ovary (CHO cell)
Purity : >95%as determined by SDS-PAGE and HPLC
Endotoxin : <1.0EU per 10 mg protein as determined by the LAL method
Stability : Samplesare stable for up to six months from date of receipt at -20℃ and are stable fortwo months at 4℃.
Molecular Mass : TFIcontains 619 amino acid residues, monomer molecular weight is about 68kDa,double body weight is about 136kDa.
Predicted N terminal : LPAQVAFTPY
Formulation : Normally1mM PB, 80mM Sodium Chloride and 0.05 mg/ml Tween-80 are added, pH 7.4.
Storage : Store itunder sterile conditions at -70℃upon receiving. Recommend to pack the protein intosmaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
BACKGROUND :
IntroductionA tumor necrosisfactor receptor (TNFR), or death receptor, is a trimeric cytokine receptorthat binds tumor necrosis factors (TNF). The receptor cooperates with anadaptor protein (such as TRADD, TRAF, RIP), which is important in determiningthe outcome of the response. The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans isencoded by the IL1RN gene. IL-1RA wasinitially called the IL-1 inhibitor and was discovered separately in 1984 bytwo independent laboratories. IL-1RA,is an agent that binds non-productively to the cell surface interleukin-1receptor (IL-1R).IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 fromsending a signal to that cell.
KeywordsIL1RN;interleukin 1 receptor antagonist; DIRA; ICIL-1RA; IL-1RN; IL-1ra; IL-1ra3;TNFRII-Fc; TNF; tumor necrosis factor

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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