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Active Recombinant Human G Protein-Coupled Receptor 115, His-tagged

Cat.No. : GPR115-5631H
Product Overview : RecombinantHuman GPR115 protein was expressed in Chinese HamsterOvary cell line. Ser22-Ala347, with a C-terminal 6-Histag.
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Cat. No. : GPR115-5631H
Description : GPR115 is a member of the LN-7TM family of adhesion-type7-transmembrane (TM) G-protein coupled receptors (GPCR) that show a longextracellular N-terminus. The 695 amino acid (aa) human GPR115 sequencepredicts a 21 aa signal sequence, a 385 aa N-terminal extracellular domain(ECD), seven TM regions separated by 6-24 aa intracellular and extracellularregions, and a 40 aa cytoplasmic tail. Like other LN-7TM members, the ECDcontains a highly glycosylated mucin-like stalk that is predicted to functionin adhesion. This is followed by a cysteine-rich GPCR proteolytic cleavagesite (GPS).
Source : Chinese HamsterOvary cell line, CHO-derived.
Form : Lyophilized from a0.2 um filtered solution in PBS.
N-terminalSequence : Ser22
MolecularWeight : 37 kDa
Activity : Measuredby the ability of the immobilized protein to support the adhesion of U-87 MGhuman glioblastoma/astrocytoma cells. When 5x104 cells per wellare added to rhGPR115 coated plates (5 μg/mL, 100 μL/well), approximately 60-85%will adhere after 60 minutes at 37°C.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 66-100kDa, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 200 μg/mLin sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 monthsfrom date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C understerile conditions after reconstitution. 3 months, -20 to -70 °C understerile conditions after reconstitution.
Gene Name : GPR115 G protein-coupledreceptor 115 [ Homo sapiens ]
Official Symbol : GPR115
Synonyms : GPR115; Gprotein-coupled receptor 115; PGR18; probable G-protein coupled receptor115; G-protein coupled receptor PGR18; seven transmembrane helix receptor
Gene ID : 221393
mRNA Refseq : NM_153838
Protein Refseq : NP_722580
MIM : 614268
UniProt ID : Q8IZF3
Chromosome Location : 6p12.3
Function : G-protein coupledreceptor activity; receptor activity; signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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