"KREMEN2" Related Products

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Recombinant Human Kringle Containing Transmembrane Protein 2, His-tagged

Cat. No.: KREMEN2-5674H
Product Overview: Recombinant Human KREMEN2protein was expressed in Murine myeloma cell line with a C-terminal 10-Histag. Gln19-Ala364.
Description: KREMEN2 proteins aretype I transmembrane proteins that contain extracellular kringle, WSC and CUBdomains and an intracellular region without any conserved motifs. Two relatedmembers, KREMEN1, and 2, have been identified. KREMEN bind a subset of thesecreted Dickkopf proteins (Dkk1, 2, and 4) with high affinity to modulatethe canonical Wnt signaling pathway that is transduced by the ternaryreceptor complex composed of Wnt, the seventransmembrane domain receptorFrizzled, and the LDLreceptorrelated protein 5/6 coreceptor.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 μm filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence: Gln19 predicted
Molecular Weight: 38 kDa
Activity: Measuredby its binding ability in a functional ELISA. Immobilized rhKREMEN2/ his at 4μg/mL (100 μL/well) can bind rhDkk1 with an apparent KD < 10nM.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 59-63kDa, reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 100μg/mL in sterile PBS
Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Gene Name: KREMEN2 kringle containingtransmembrane protein 2 [ Homo sapiens ]
Official Symbol: KREMEN2
Synonyms: KREMEN2; kringlecontaining transmembrane protein 2; KRM2; MGC10791; MGC16709; kremen protein2; dickkopf receptor 2; kringle domain-containing transmembrane protein 2;kringle-containing protein marking the eye and the nose; OTTHUMP00000159226;OTTHUMP00000159227
Gene ID: 79412
mRNA Refseq: NM_024507
Protein Refseq: NP_078783
MIM: 609899
UniProt ID: Q8NCW0
Chromosome Location: 16p13.11
Pathway: Presenilin action inNotch and Wnt signaling; Wnt signaling network

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