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| Cat. No.: | Hgf-734M |
| Product Overview: | Recombinant Mouse Hgfprotein was expressed in Murine myeloma cell line. Gln33-Arg495 (alpha) &Val496-Leu728 (beta). |
| Description: | Hgf, also known asScatter Factor and Hepatopoietin A, is a pleiotropic protein in thePlasminogen subfamily of S1 peptidases. It is a multidomain molecule thatincludes an N-terminal PAN/APPLE-like domain, four Kringle domains, and aserine proteinase-like domain that has no detectable protease activity. MouseHgf is secreted as an inactive 728 amino acid (aa) single chain propeptide. |
| Source: | Murine myeloma cellline, NS0-derived. |
| Form: | Lyophilized from a0.2 μm filtered solution in PBS with BSA as a carrier protein. |
| N-terminalSequence: | Gln33 predicted(alpha) & Val496 (beta) |
| Molecular Weight: | 53.4 kDa (α-chain),26 kDa (β-chain) |
| Activity: | Measuredin a cell proliferation assay using IMCD3 mouse epithelial cells. The ED50for this effect is typically 10-30 ng/mL. Measured by its ability to bindRecombinant Mouse Met Fc Chimera in a functional ELISA with an estimated KD< 0.2 nM. |
| Endotoxin Level: | <1.0 EUper 1 μg of the protein by the LAL method. |
| SDS-PAGE: | 60 kDaand 33 kDa, reducing conditions. |
| Purity: | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution: | 10 μg/mLin sterile PBS that containing at least 0.1% human or bovine serum albumin. |
| Storage: | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution. |
| Gene Name: | Hgf hepatocyte growth factor [ Musmusculus ] |
| Official Symbol: | Hgf |
| Synonyms: | Hgf; hepatocytegrowth factor; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik; SF; scatter factor;hepatopoeitin-A; Scatter factor |
| Gene ID: | 15234 |
| mRNA Refseq: | NM_010427 |
| Protein Refseq: | NP_034557 |
| UniProt ID: | Q08048 |
| Chromosome Location: | 5 A2-A3; 5 4.0 cM |
| Pathway: | Cytokine-cytokinereceptor interaction; Focal Adhesion; Focal adhesion; Hemostasis; Malaria;Melanoma; Pathways in cancer; Platelet activation; Platelet degranulation;Renal cell carcinoma; Response to elevated platelet cytosolic Ca2+;Signaling of Hepatocyte Growth Factor Receptor |
| Function: | catalytic activity;growth factor activity; protein heterodimerization activity; serine-typeendopeptidase activity |
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