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Recombinant Rat Unc-5 Homolog A (C. elegans), Fc-tagged

Cat. No.: Unc5a-513R
Product Overview: Recombinant Rat Unc5aprotein was expressed in Murine myeloma cell line with the Fc part of HumanIgG1 Pro100-Lys330 (C-terminus) and Gln26-Asp358 (N-terminus).
Description: Unc5a is a member ofthe UNC5 family of type I transmembrane proteins within the immunoglobulinsuperfamily. UNC5H14 have two Ig and one or two thrombospondin type 1 domainin their extracellular regions, and a ZU5 domain, a DCC binding domain and aC-terminal death domain in their cytoplasmic regions. Rat Unc5a cDNA encodes898 amino acids including a 25 aa signal peptide, a 336 aa extracellulardomain with two TSP1 domains, and a 516 aa cytoplasmic domain.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Gln26 predicted
Molecular Weight: 63.4 kDa
Activity: Measuredby its binding ability in a functional ELISA. Immobilized rr Unc5a/Fc Chimera at 5 μg/ mL (100 μL/ well) can bind rchNetrin-1with a linear range of 6-400 ng/mL.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 85-95kDa & 40-43 kDa, reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 100 μg/ mLin sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Unc5a unc-5 homolog A (C.elegans) [ Rattus norvegicus ]
Official Symbol: Unc5a
Synonyms: Unc5a; unc-5homolog A (C. elegans); Unc5h1; netrin receptor UNC5A; unc-5 homolog 1;protein unc-5 homolog 1; protein unc-5 homolog A; transmembrane receptorUnc5H1
Gene ID: 60629
mRNA Refseq: NM_022206
Protein Refseq: NP_071542
UniProt ID: O08721
Chromosome Location: 17p14
Pathway: Apoptosis; Axonguidance; Developmental Biology; Netrin mediated repulsion signals; Netrin-1signaling; Regulation of Apoptosis; Role of DCC in regulating apoptosis
Function: netrin receptoractivity; receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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