"WNT4" Related Products

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Recombinant Human Wingless-Type MMTV Integration Site Family, Member 4

Cat. No.: WNT4-516H
Product Overview: Recombinant Human WNT4protein was expressed in Chinese Hamster Ovary cell line. Ser23-Arg351.
Description: WNT4 is a 38-42kDamember of the Wnt family of secreted glycoproteins, which act as shortrange signalingmolecules via Frizzled receptors and a cascade of intracellular signals invertebrate embryogenesis. Human WNT4 is synthesized as a 351 amino acid (aa)precursor with a 22 aa signal sequence and a 329 aa mature chain. The maturechain contains two potential sites for Nlinked glycosylation. Relative toother members of the Wnt family, WNT4 contains 83 conserved aa, including 21cysteines.
Source: Chinese HamsterOvary cell line, CHO-derived.
Form: Lyophilized from a0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrierprotein.
N-terminalSequence: Ser23
Molecular Weight: 39.1 kDa
Activity: Measured by itsability to induce alkaline phosphatase production by MC3T3E1 mouseosteoblastic cells. The typical ED50 for this effect is 25-100 ng/mL.
Endotoxin Level: < 1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE: 42 - 80 kDa,reducing conditions.
Purity: > 60%, by SDSPAGEunder reducing conditions and visualized by silver stain.
Reconstitution: 50 μg/mL in PBS.
Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: WNT4 wingless-type MMTVintegration site family, member 4 [ Homo sapiens ]
Official Symbol: WNT4
Synonyms: WNT4; wingless-typeMMTV integration site family, member 4; WNT-4; SERKAL; protein Wnt-4; UNQ426/PRO864
Gene ID: 54361
mRNA Refseq: NM_030761
Protein Refseq: NP_110388
MIM: 603490
UniProt ID: P56705
Chromosome Location: 1p36.23-p35.1
Pathway: Basal cell carcinoma;Class B/2 (Secretin family receptors); DNA damage response (only ATMdependent); GPCR ligand binding; HTLV-I infection; Hedgehog signaling pathway;Melanogenesis; Pathways in cancer; Signal Transduction; Signaling by GPCR; WntSignaling Pathway; Wnt Signaling Pathway NetPath; Wnt Signaling Pathway andPluripotency; Wnt signaling pathway
Function: G-protein coupledreceptor binding; extracellular matrix structural constituent; frizzledbinding; transcription corepressor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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