"ADAMTS15" Related Products


Recombinant Human ADAM Metallopeptidase With Thrombospondin type 1 Motif, 15, His-tagged

Cat. No. : ADAMTS15-528H
Product Overview : Recombinant Human ADAMTS15protein was expressed in Chinese Hamster Ovary cell line with a C-terminal 10-Histag. Gly18-Cys682 (pro) & Phe213-Cys682 (mature).
Description : ADAMTS (adisintegrin and metalloproteinase with thrombospondin motifs) is a group ofnineteen secreted zinc binding metalloproteases that is involved indevelopment, inflammation, angiogenesis and several pathological conditions.They are synthesized as zymogens which have a prodomain that is removed byfurinlike protein convertases. The mature secreted enzymes consist ofcatalytic, disintegrinlike, type I thrombospondin (TSP) motif, cysteine rich,and spacer domains followed by zero to fourteen additional TSP motifs.
Source : Chinese HamsterOvary cell line, CHO-derived.
Form : Supplied as a 0.2 μmfiltered solution in MES and NaCl.
N-terminalSequence : Gly18 & Phe213
Molecular Weight : 74 kDa (pro), 53 kDa(mature)
Activity : Measured by itsability to cleave rhAggrecan. Cleavage of 1 μg of rhAggrecan is > 90%, asmeasured under the described conditions.
Endotoxin Level : < 1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE : 85 kDa and 65 kDa,reducing conditions.
Purity : > 80%, by SDSPAGEunder reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mL in sterilePBS.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt,-20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditionsafter opening.
Gene Name : ADAMTS15 ADAM metallopeptidasewith thrombospondin type 1 motif, 15 [ Homo sapiens ]
Official Symbol : ADAMTS15
Synonyms : ADAMTS15; ADAMmetallopeptidase with thrombospondin type 1 motif, 15; Adisintegrin and metalloproteinase with thrombospondin motifs 15; ADAM-TS15;ADAMTS-15; ADAM-TS 15; metalloprotease disintegrin 15 with thrombospondindomains; a disintegrin-like and metalloprotease (reprolysin type) withthrombospondin type 1 motif, 15, preproprotein
Gene ID : 170689
mRNA Refseq : NM_139055
Protein Refseq : NP_620686
MIM : 607509
UniProt ID : Q8TE58
Chromosome Location : 11q25
Function : metal ion binding;metalloendopeptidase activity; peptidase activity; zinc ion binding

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