"BMP15" Related Products

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Recombinant Human Bone Morphogenetic Protein 15

Cat. No.: BMP15-579H
Product Overview: Recombinant Human BMP15protein was expressed in Chinese Hamster Ovary cell line. Gln268-Arg392.
Description: Bone morphogeneticprotein 15 (BMP15), also known as GDF9B, is a TGFβ superfamily ligand that isexpressed by oocytes throughout folliculogenesis, and plays an important rolein oocyte development. BMP15 promotes the FSHindependent proliferation ofovarian granulosa cells (GC) and induces GC glycolysis and cholesterolsynthesis. It also induces GC production of stem cell factor which, in turn,negatively regulates BMP15 expression in oocytes.
Source: Chinese HamsterOvary cell line, CHO-derived.
Form: Lyophilized from a0.2 μm filtered solution in HCl with BSA as a carrier protein.
N-terminalSequence: Gln268
Molecular Weight: 13.9 kDa
Activity: Measured by itsability to induce Smad3 phosphorylation in P19 mouse embryonal carcinomacells. Approximately 10 ng/mL can effectively induce Smad3 phosphorylation.
Endotoxin Level: < 1.0EU per 1 μg of the protein by the LAL method.
SDS-PAGE: 15 kDa,reducing conditions.
Purity: > 90%, by SDSPAGEunder reducing conditions and visualized by silver stain.
Reconstitution: 100 μg/mL in sterile4 mM HCl containing at least 0.1% human or bovine serum albumin.
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: BMP15 bone morphogenetic protein15 [ Homo sapiens ]
Official Symbol: BMP15
Synonyms: BMP15; bonemorphogenetic protein 15; ODG2; POF4; GDF9B; BMP-15; GDF-9B;growth/differentiation factor 9B
Gene ID: 9210
mRNA Refseq: NM_005448
Protein Refseq: NP_005439
MIM: 300247
UniProt ID: O95972
Chromosome Location: Xp11.2
Function: cytokine activity;growth factor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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