"BMP8A" Related Products

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Recombinant Human Bone Morphogenetic Protein 8a

Cat. No.: BMP8A-587H
Product Overview: Recombinant Human BMP8Aprotein was expressed in Chinese Hamster Ovary cell line. Ala264-His402.
Description: BMP8A, also known asosteogenic protein 2 (OP-2), was first isolated from a hippocampal library ina screen to identify relatives of BMP-7/OP-1. BMPs are a family ofstructurally and functionally related proteins and represent a subfamily ofthe transforming growth factor β (TGF-β) superfamily. BMPs are involved in awide range of processes including embryogenesis, tissue morphogenesis, cell differentiationand migration, and tumorigenesis. Cellular responses to BMPs are mediated by heterooligomericcomplexes of type I and type II serine/threonine kinase receptors.
Source: Chinese HamsterOvary cell line, CHO-derived.
Form: Lyophilized from a0.2 μm filtered solution in HCl.
N-terminalSequence: Ala264
Molecular Weight: 15.7 kDa (monomer)
Activity: Measured by itsability to inhibit the cell growth of DU145 human prostate carcinoma cells. TheED50 for this effect is typically 0.2-1 μg/mL.
Endotoxin Level: < 1.0EU per 1 μg of the protein by the LAL method.
SDS-PAGE: 19 kDa,reducing conditions.
Purity: > 95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 250 μg/mL in 4 mMHCl.
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: BMP8A bone morphogeneticprotein 8a [ Homo sapiens ]
Official Symbol: BMP8A
Synonyms: BMP8A; bonemorphogenetic protein 8a; bone morphogenetic protein 8A; BMP-8A
Gene ID: 353500
mRNA Refseq: NM_181809
Protein Refseq: NP_861525
UniProt ID: Q7Z5Y6
Chromosome Location: 1p35-p32
Pathway: Hedgehog signalingpathway; TGF-beta signaling pathway
Function: cytokine activity;growth factor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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