"Gas1" Related Products

Recombinant Mouse Growth Arrest Specific 1, His-tagged

Cat. No. : Gas1-605M
Product Overview : RecombinantMouse Gas1 protein was expressed in Murine myeloma cell line. Leu39-Ser315& Arg43-Ser315, both with a C-terminal 6-His tag.
Description : Gas1 isone of six structurally unrelated proteins that were identified by theirincreased expression in growth-arrested cells relative to activelyproliferating cells. Following mitogenic stimulation, Gas1 expression is transcriptionallysuppressed by c-Myc as cells transit from G 0 to G1 phases of the cell cycle.Overexpression of Gas1 prevents S phase entry and DNA synthesis. Gas-mediatedblockade of the cell cycle is p53-dependent but does not require thetransactivating domain of p53. The mouse Gas1 cDNA encodes a 343 amino acid(aa) precursor that includes a 38 aa signal sequence, a 277 aa matureprotein, and a 28 aa C-terminal propeptide. Gas1 contains Ala-rich and Asp-richregions as well as an RGD sequence.
Source : Murine myeloma cellline, NS0-derived.
Form : Lyophilized from a0.2 um filtered solution in PBS.
N-terminalSequence : Leu39 & Arg43
MolecularWeight : 29.8 kDa
Activity : Measuredby its binding ability in a functional ELISA. Immobilized rhGas1 at 1 μg/mL(100 μL/well) can bind rmArtemin at a linear range of 0.1-10 ng/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 40 kDa,reducing conditions.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at100μg/mL in PBS.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name : Gas1 growth arrest specific 1 [Mus musculus ]
Official Symbol : Gas1
Synonyms : Gas1; growth arrestspecific 1; Gas-1;AW554192; growth arrest-specific protein 1
Gene ID : 14451
mRNA Refseq : NM_008086
Protein Refseq : NP_032112
UniProt ID : Q01721
Chromosome Location : 13
Pathway : Hedgehog SignalingPathway
Function : protein binding

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