"Gas1" Related Products

Recombinant Mouse Growth Arrest Specific 1, His-tagged

Cat. No.: Gas1-605M
Product Overview: RecombinantMouse Gas1 protein was expressed in Murine myeloma cell line. Leu39-Ser315& Arg43-Ser315, both with a C-terminal 6-His tag.
Description: Gas1 isone of six structurally unrelated proteins that were identified by theirincreased expression in growth-arrested cells relative to activelyproliferating cells. Following mitogenic stimulation, Gas1 expression is transcriptionallysuppressed by c-Myc as cells transit from G 0 to G1 phases of the cell cycle.Overexpression of Gas1 prevents S phase entry and DNA synthesis. Gas-mediatedblockade of the cell cycle is p53-dependent but does not require thetransactivating domain of p53. The mouse Gas1 cDNA encodes a 343 amino acid(aa) precursor that includes a 38 aa signal sequence, a 277 aa matureprotein, and a 28 aa C-terminal propeptide. Gas1 contains Ala-rich and Asp-richregions as well as an RGD sequence.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 um filtered solution in PBS.
N-terminalSequence: Leu39 & Arg43
MolecularWeight: 29.8 kDa
Activity: Measuredby its binding ability in a functional ELISA. Immobilized rhGas1 at 1 μg/mL(100 μL/well) can bind rmArtemin at a linear range of 0.1-10 ng/mL.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 40 kDa,reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstitute at100μg/mL in PBS.
Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name: Gas1 growth arrest specific 1 [Mus musculus ]
Official Symbol: Gas1
Synonyms: Gas1; growth arrestspecific 1; Gas-1;AW554192; growth arrest-specific protein 1
Gene ID: 14451
mRNA Refseq: NM_008086
Protein Refseq: NP_032112
UniProt ID: Q01721
Chromosome Location: 13
Pathway: Hedgehog SignalingPathway
Function: protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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