Active Recombinant Human Growth Arrest-Specific 1, His-tagged
Cat.No. : | GAS1-609H |
Product Overview : | RecombinantHuman GAS1 protein was expressed in Murinemyeloma cell line. Leu40-Ser318, with a C-terminal 6-Histag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | GAS1-609H |
Description : | GAS1 is one of six structurally unrelated proteins thatwere identified by their increased expression in growth-arrested cells relativeto actively proliferating cells. Following mitogenic stimulation, GAS1 expression is transcriptionally suppressed by c-Myc ascells transit from G 0 to G1 phases of the cell cycle. Overexpression of GAS1 prevents S phase entry and DNA synthesis. GAS1-mediated blockade of the cell cycle is p53-dependent butdoes not require the transactivating domain of p53. The human GAS1 cDNA encodes a 345 amino acid (aa) precursor thatincludes a 39 aa signal sequence, a 279 aa mature protein, and a 27 aa C-terminalpropeptide. GAS1 contains Ala-rich and Asp-rich regions as well as anRGD sequence. |
Source : | Mammalian cells |
Form : | Supplied as a 0.2 umfiltered solution in Tris and NaCl. |
N-terminalSequence : | Leu40 |
MolecularWeight : | 30.1 kDa |
Activity : | Measuredby its binding ability in a functional ELISA. Immobilized rhGas1 at 1 μg/mL(10μL/well) can bind rmArtemin at a linear range of 0.1-10 ng/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 40 kDa,reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 100μg/mL in sterile PBS. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening. |
Gene Name : | GAS1 growth arrest-specific 1 [ Homosapiens ] |
Official Symbol : | GAS1 |
Synonyms : | GAS1; growth arrest-specific 1;growth arrest-specific protein 1; Growth arrest specific gene 1;Growth-arrest-specific protein 1 precursor; GAS-1; OTTHUMP00000021599; Growtharrest-specific gene-1 |
Gene ID : | 2619 |
mRNA Refseq : | NM_002048 |
Protein Refseq : | NP_002039 |
MIM : | 139185 |
UniProt ID : | P54826 |
Chromosome Location : | 9q21.3-q22 |
Pathway : | FOXM1 transcriptionfactor network; Hedgehog Signaling Pathway; Signaling events mediated by theHedgehog family |
Function : | protein binding |
Products Types
◆ Recombinant Protein | ||
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Gas1-3472M | Recombinant Mouse Gas1 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAS1-13160H | Recombinant Human GAS1, His-tagged | +Inquiry |
GAS1-223H | Recombinant Human GAS1 | +Inquiry |
GAS1-6213M | Recombinant Mouse GAS1 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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