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Active Recombinant Human Growth Arrest-Specific 6, His-tagged

Cat.No. : GAS6-613H
Product Overview : RecombinantHuman GAS6 protein was expressed in Murinemyeloma cell line. Ala49-Ala678, with a C-terminal 6-Histag.
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Cat. No. : GAS6-613H
Description : GAS6 is a multimodular protein that is upregulated by awide variety of cell types in response to growth arrest. GAS6 and the structurally related Protein S are vitamin Kdependentand have an extensively γ-carboxylated N-terminal Gla domain, four EGF-like repeats,and a C-terminal region with homology to steroid hormone binding globulin(SHBG). Human GAS6 is a 75 kDa proteinthat shares 77%-79% aa sequence identity with mouse and rat GAS6, and 43% aa identity with human protein S (over the regionexpressed). GAS6 binds and induces signaling through the receptortyrosine kinases Axl, Dtk, and Mer. Human GAS6 interactswith both mouse and rat orthologs of these receptors.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in Tris, NaCl and Citrate.
N-terminalSequence : Ala49
MolecularWeight : 70.5 kDa
Activity : Measuredin a cell proliferation assay using T98G human glioblastoma cells. The ED50 forthis effect is typically 100-400 ng/mL. Also measured by its ability to bindRecombinant Human Axl Fc Chimera in a functional ELISA.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 70-85kDa, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100μg/mL in sterile H2O.
Storage : Use a manual defrost freezer and avoid repeated freezethawcycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name : GAS6 growth arrest-specific 6 [ Homosapiens ]
Official Symbol : GAS6
Synonyms : GAS6; growtharrest-specific 6; AXSF; AXLLG; AXLstimulatory factor; AXL receptor tyrosine kinase ligand
Gene ID : 2621
mRNA Refseq : NM_000820
Protein Refseq : NP_000811
MIM : 600441
UniProt ID : Q14393
Chromosome Location : 13q34
Pathway : Cell surfaceinteractions at the vascular wall; Gamma-carboxylation of protein precursors;Gamma-carboxylation; Platelet activation; Hemostasis; Metabolism of proteins;Platelet degranulation; Post-translational protein modification; Removal ofaminoterminal propeptides from gamma-carboxylated proteins; Transport ofgamma-carboxylated protein precursors from the endoplasmic reticulum to theGolgi apparatus
Function : calcium ion binding;receptor agonist activity; receptor binding; receptor tyrosine kinase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How are GAS6 protein expression levels associated with cardiovascular disease? 02/28/2022

Expression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.

How does GAS6 protein relate to other biomarkers? 12/13/2021

The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.

What is the role of GAS6 protein in tumor treatment? 01/24/2020

GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.

What is the role of GAS6 protein in the treatment of cardiovascular disease? 11/20/2019

Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore

How to use the expression level of GAS6 protein for tumor diagnosis and prognosis assessment? 11/02/2019

It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.

How is GAS6 protein expression related to tumors? 05/16/2019

Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.

Customer Reviews (3)

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Reviews
12/17/2022

    GAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.

    08/16/2022

      The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.

      07/06/2021

        Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.

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