"GAS6" Related Products

Expand
Expand
Expand

Recombinant Human Growth Arrest-Specific 6, His-tagged

Cat. No.: GAS6-613H
Product Overview: RecombinantHuman GAS6 protein was expressed in Murinemyeloma cell line. Ala49-Ala678, with a C-terminal 6-Histag.
Description: GAS6 is a multimodular protein that is upregulated by awide variety of cell types in response to growth arrest. GAS6 and the structurally related Protein S are vitamin Kdependentand have an extensively γ-carboxylated N-terminal Gla domain, four EGF-like repeats,and a C-terminal region with homology to steroid hormone binding globulin(SHBG). Human GAS6 is a 75 kDa proteinthat shares 77%-79% aa sequence identity with mouse and rat GAS6, and 43% aa identity with human protein S (over the regionexpressed). GAS6 binds and induces signaling through the receptortyrosine kinases Axl, Dtk, and Mer. Human GAS6 interactswith both mouse and rat orthologs of these receptors.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 μm filtered solution in Tris, NaCl and Citrate.
N-terminalSequence: Ala49
MolecularWeight: 70.5 kDa
Activity: Measuredin a cell proliferation assay using T98G human glioblastoma cells. The ED50 forthis effect is typically 100-400 ng/mL. Also measured by its ability to bindRecombinant Human Axl Fc Chimera in a functional ELISA.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 70-85kDa, reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100μg/mL in sterile H2O.
Storage: Use a manual defrost freezer and avoid repeated freezethawcycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name: GAS6 growth arrest-specific 6 [ Homosapiens ]
Official Symbol: GAS6
Synonyms: GAS6; growtharrest-specific 6; AXSF; AXLLG; AXLstimulatory factor; AXL receptor tyrosine kinase ligand
Gene ID: 2621
mRNA Refseq: NM_000820
Protein Refseq: NP_000811
MIM: 600441
UniProt ID: Q14393
Chromosome Location: 13q34
Pathway: Cell surfaceinteractions at the vascular wall; Gamma-carboxylation of protein precursors;Gamma-carboxylation; Platelet activation; Hemostasis; Metabolism of proteins;Platelet degranulation; Post-translational protein modification; Removal ofaminoterminal propeptides from gamma-carboxylated proteins; Transport ofgamma-carboxylated protein precursors from the endoplasmic reticulum to theGolgi apparatus
Function: calcium ion binding;receptor agonist activity; receptor binding; receptor tyrosine kinase binding

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.