Active Recombinant Human Growth Arrest-Specific 6, His-tagged
Cat.No. : | GAS6-613H |
Product Overview : | RecombinantHuman GAS6 protein was expressed in Murinemyeloma cell line. Ala49-Ala678, with a C-terminal 6-Histag. |
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- Gene Information
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Cat. No. : | GAS6-613H |
Description : | GAS6 is a multimodular protein that is upregulated by awide variety of cell types in response to growth arrest. GAS6 and the structurally related Protein S are vitamin Kdependentand have an extensively γ-carboxylated N-terminal Gla domain, four EGF-like repeats,and a C-terminal region with homology to steroid hormone binding globulin(SHBG). Human GAS6 is a 75 kDa proteinthat shares 77%-79% aa sequence identity with mouse and rat GAS6, and 43% aa identity with human protein S (over the regionexpressed). GAS6 binds and induces signaling through the receptortyrosine kinases Axl, Dtk, and Mer. Human GAS6 interactswith both mouse and rat orthologs of these receptors. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in Tris, NaCl and Citrate. |
N-terminalSequence : | Ala49 |
MolecularWeight : | 70.5 kDa |
Activity : | Measuredin a cell proliferation assay using T98G human glioblastoma cells. The ED50 forthis effect is typically 100-400 ng/mL. Also measured by its ability to bindRecombinant Human Axl Fc Chimera in a functional ELISA. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 70-85kDa, reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 100μg/mL in sterile H2O. |
Storage : | Use a manual defrost freezer and avoid repeated freezethawcycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution. |
Gene Name : | GAS6 growth arrest-specific 6 [ Homosapiens ] |
Official Symbol : | GAS6 |
Synonyms : | GAS6; growtharrest-specific 6; AXSF; AXLLG; AXLstimulatory factor; AXL receptor tyrosine kinase ligand |
Gene ID : | 2621 |
mRNA Refseq : | NM_000820 |
Protein Refseq : | NP_000811 |
MIM : | 600441 |
UniProt ID : | Q14393 |
Chromosome Location : | 13q34 |
Pathway : | Cell surfaceinteractions at the vascular wall; Gamma-carboxylation of protein precursors;Gamma-carboxylation; Platelet activation; Hemostasis; Metabolism of proteins;Platelet degranulation; Post-translational protein modification; Removal ofaminoterminal propeptides from gamma-carboxylated proteins; Transport ofgamma-carboxylated protein precursors from the endoplasmic reticulum to theGolgi apparatus |
Function : | calcium ion binding;receptor agonist activity; receptor binding; receptor tyrosine kinase binding |
Products Types
◆ Recombinant Protein | ||
GAS6-288TH | Recombinant Human GAS6 full-length, GST-tagged | +Inquiry |
GAS6-3014H | Recombinant Human GAS6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Gas6-3478M | Recombinant Mouse Gas6 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAS6-898M | Recombinant Mouse GAS6 Protein (Met1-Pro674), His-tagged | +Inquiry |
Gas6-1563R | Recombinant Rat Gas6 Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
GAS6-6017HCL | Recombinant Human GAS6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionExpression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.
The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.
GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.
Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore
It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.
Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.
Customer Reviews (3)
Write a reviewGAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.
The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.
Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.
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