"Kel" Related Products


Recombinant Mouse Kell Blood Group, His-tagged

Cat. No.: Kel-1976M
Product Overview: RecombinantMouse Kel protein was expressed in Murine myeloma cell line. Phe50-Trp713,with an N-terminal 7-His tag.
Description: Kel islinked through a single disulfide bond to XK, a putative membranetransporter. The two proteins constitute the Kel bloodgroup antigens. Kel is a zinc endopeptidase of the neprilysin(NEP) family which also includes endothelin converting enzymes (ECE-1 and ECE-2),PEX, XCE, DINE and several NEP-like proteins. It has been shown to cleave bigendothelin-3 (ET-3) at Trp21-Ile22, yielding ET-3, and to a much lesserextent, big ET-1 and big ET-2 at Trp21-Val22, yielding ET-1 and ET-2. Severaldifferent molecular defects cause the Kel null phenotype,which has no obvious clinical outcome.
Source: Murine myeloma cellline, NS0-derived.
Form: Supplied as a 0.2 umfiltered solution in Tris, NaCl and ZnCl2.
N-terminalSequence: His
MolecularWeight: 76 kDa
Activity: Measuredby its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH.The specific activity is > 0.2 pmoles/min/μg, as measured under thedescribed conditions.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 106 kDa,reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Use a manual defrost freezer and avoid repeated freezethawcycles. 6months from date of receipt, -20 to -70°C as supplied. 3 months, -20 to -70°Cunder sterile conditions after opening.
Gene Name: Kel Kell blood group [ Musmusculus ]
Official Symbol: Kel
Synonyms: Kel; Kell bloodgroup; Ece3;CD238; kell blood group glycoprotein homolog; Kell protein; Kel blood groupprotein; Kell blood group, metallo-endopeptidase
Gene ID: 23925
mRNA Refseq: NM_032540
Protein Refseq: NP_115929
UniProt ID: Q9EQF2
Chromosome Location: 6
Function: endopeptidase activity;hydrolase activity; metal ion binding; metalloendopeptidase activity;metallopeptidase activity; peptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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