"LOXL3" Related Products


Recombinant Human Lysyl Oxidase-Like 3, His-tagged

Cat. No.: LOXL3-1979H
Product Overview: RecombinantHuman LOXL3 protein was expressed in Chinese HamsterOvary cell line. Met1-Ile753, with a C-terminal 10-Histag.
Description: LOXL3 is asecreted copper amine oxidase. The N-terminal region of LOXL3 contains fourscavenger receptor cysteinerich (SRCR) domains. The C-terminal regionconsists of a catalytic domain similar to other lysyl oxidases and a cytokinereceptor-like domain. The catalytic domain contains conserved residues requiredfor copper binding and formation of a lysyl tyrosylquinone cofactor. LOXL3 isexpressed primarily in epidermis, kidney, aorta, and chondrocytes. The enzymeis expressed at low levels in most other tissues. Like lysyl oxidase, LOXL3oxidizes the lysine ε-amino groups of a number of collagen substrates, and isalso active against other primary amines. However, LOXL3 does not requireproteolytic processing to be activated.
Source: Chinese HamsterOvary cell line, CHO-derived.
Form: Supplied as a 0.2 μmfiltered solution in MES and NaCl.
N-terminalSequence: Ser26
MolecularWeight: 82 kDa
Activity: Measuredby its ability to produce hydrogen peroxide during the oxidation of benzylamine.The specific activity is > 1.5 pmoles/min/μg, as measured under the describedconditions.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 90-100kDa, reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by Colloidal CoomassieBlue stain at 5 μg per lane.
Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening.
Gene Name: LOXL3 lysyl oxidase-like 3 [ Homosapiens ]
Official Symbol: LOXL3
Synonyms: LOXL3; lysyloxidase-like 3; LOXL; lysyl oxidase homolog 3; lysyl oxidase-likeprotein 3; EC
Gene ID: 84695
mRNA Refseq: NM_032603
Protein Refseq: NP_115992
MIM: 607163
UniProt ID: P58215
Chromosome Location: 2p13
Function: copper ion binding;metal ion binding; oxidoreductase activity; oxidoreductase activity, actingon the CH-NH2 group of donors, oxygen as acceptor; protein-lysine 6-oxidaseactivity; scavenger receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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