"MEP1B" Related Products


Recombinant Human Meprin A, Beta, His-tagged

Cat. No.: MEP1B-1980H
Product Overview: RecombinantHuman MEP1B protein was expressed in Murine myeloma cellline. Leu21-Ser593& Thr23-Ser593, both with a C-terminal 10-His tag.
Description: Meprinsare multimeric proteases composed of α and β subunits, which are members ofthe astacin family of zinc endopeptidases. Both subunits form disulfide-linkedhomo-or eterooligomers, which are also referred to as Merpin A (composed of αsubunits with or without β subunits) and MEP1B (composedof β subunits only). Although the two subunits share 42% identity in theiramino acid sequence, they differ significantly in their oligomeric structure,posttranslational processing and subsequently cellular location, andsubstrate and peptide bond specificity.
Source: Murine myeloma cellline, NS0-derived.
Form: Supplied as a 0.2 μmfiltered solution in Tris, NaCl and Glycerol.
N-terminalSequence: Leu21 & Thr23
MolecularWeight: 66 kDa
Activity: Measuredby its ability to cleave a fluorogenic peptide substrate, McaSEVNLDAEFRK(Dpn)RR-NH2,The specific activity is > 350 pmoles/min/μg, as measured under thedescribed conditions.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 85 kDa,reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening.
Gene Name: MEP1B meprin A, beta [ Homosapiens ]
Official Symbol: MEP1B
Synonyms: MEP1B; meprin A,beta; meprin A subunit beta; PPH beta; meprin B; endopeptidase-2; PABApeptide hydrolase; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunitbeta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; EC
Gene ID: 4225
mRNA Refseq: NM_005925
Protein Refseq: NP_005916
MIM: 600389
UniProt ID: Q16820
Chromosome Location: 18q12.2-q12.3
Pathway: Protein digestion and absorption
Function: metal ion binding; metalloendopeptidaseactivity; peptidase activity; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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