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Recombinant Human Anti-Mullerian Hormone

Cat. No. : AMH-383H
Product Overview : RecombinantHuman AMH protein was expressed in E. coli. Ala453-Arg560.
Description : AMH is atissue-specific TGF-β superfamily growth factor. Its expression is restrictedto the Sertoli cells of fetal and postnatal testis, and to the granulosacells of postnatal ovary. The human MIS gene encodes a 553 amino acid residue(aa) prepropeptide containing a signal a sequence (1-24), a proregion (25-455),and the carboxylterminal bioactive protein (44-6553). MIS is synthesized andsecreted as a disulfide-linked homodimeric pro-protein. Proteolytic cleavageis required to generate the N-terminal pro-region and the C-terminal bioactiveprotein, which remain associated in a noncovalent complex.
Source : E. coli
Form : Lyophilizedfrom a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrierprotein.
N-terminalSequence : Ala453
MolecularWeight : 11.7 kDa (monomer)
Activity : Measuredby its ability to inhibit growth of OVCAR-3 human ovarian carcinoma cells. Measuredby its binding ability in a functional ELISA. Immobilized rhMIS at 3 μg/Ml (100μL/well) will bind rrMIS RII/Fc Chimera with a linear range of 1.6-100 ng/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 10μg/mL in sterile PBS containing at least 0.1% human or bovine serumalbumin.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : AMH anti-Mullerian hormone [ Homosapiens ]
Official Symbol : AMH
Synonyms : AMH; anti-Mullerianhormone; MIF;MIS; muellerian-inhibiting factor; Mullerian inhibiting factor; Mullerianinhibiting substance; muellerian-inhibiting substance
Gene ID : 268
mRNA Refseq : NM_000479
Protein Refseq : NP_000470
MIM : 600957
UniProt ID : P03971
Chromosome Location : 19p13.3
Pathway : Cytokine-cytokine receptor interaction; ALK2signaling events; TGF-beta signaling pathway
Function : growth factor activity; hormone activity; receptorbinding; transforming growth factor beta receptor binding

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