Recombinant Human Neurexin 2 Fc-tagged NRXN2-055H

Recombinant Human Neurexin 2 Fc-tagged


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Recombinant Human Neurexin 2 Fc-tagged

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Cat. No. : NRXN2-055H
Product Overview : Recombinant Human NRXN2protein was expressed in CHO with the Fc part of human IgG1 Pro100-Lys330(C-terminus) and Met1-Thr1566 (N-terminus).
Description : NRXN2 is a neuronaltype I transmembrane molecule that is encoded by one of three Neurexin genes.Mature human NRXN2 is an approximately 200 kDa N- and O-glycosylated proteinwith a 1608 amino acid (aa extracellular domain (ECD) and a 55 aa cytoplasmicdomain. The ECD contains six LNS domains interspersed with three EGF-likedomains and a juxtamembrane O-glycosylation region. The ECD of human NRXN2shares 98% and 99% aa sequence identity with mouse and rat NRXN2,respectively. Transcription of the NRXN2 gene from an internal promoter givesrise to NRXN2 which lacks the first five LNS domains and all of the EGF-likedomains.
Source : Chinese HamsterOvary cell line, CHO-derived
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Leu29
Molecular Weight : 193 kDa
Activity : Measuredby its binding ability in a functional ELISA. When Recombinant Human NRXN2/NRXN2 Fc Chimera is coated at 2 μg/mL, biotinylatedrecombinant rat NXPH1 binds with an apparent KD < 10 nM.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 200-250kDa, reducing conditions
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in PBS
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : NRXN2 neurexin 2 [ Homosapiens ]
Official Symbol : NRXN2
Synonyms : NRXN2; neurexin 2; FLJ40892;KIAA0921; neurexin-2-beta; neurexin II; neurexin II-beta; neurexin-2-alpha;neurexin II-alpha
Gene ID : 9379
mRNA Refseq : NM_138734
Protein Refseq : NP_620063
MIM : 600566
UniProt ID : P58401
Chromosome Location : 11q13
Pathway : Cell adhesionmolecules (CAMs)
Function : calcium channelregulator activity; cell adhesion molecule binding; metal ion binding

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