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Recombinant Mouse Cell Adhesion Molecule 1, His-tagged

Cat. No.: Cadm1-5604M
Product Overview: Recombinant Mouse Cadm1protein was expressed in Murine myeloma cell line with a C-terminal 10-Histag. Ile42-Asp376.
Description: Cadm1 is a 75 kDaimmunoglobulin superfamily protein that mediates calcium-independent adhesiveinteractions, either homophilic or heterophilic with CRTAM (classI-restricted T cell-associated molecule), Necl1 (SynCAM3) or Nectin3.Alternate names for Cadm1 reflect its activities. As Cadm1, it isdownregulated in onsmall cell lung cancer. This may allow evasion ofantitumor responses, since Cadm1 interaction with CRTAM on activated NK andCD8+ T cells stimulates cytotoxicity and upregulates IFN-γ production.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Ile42
Molecular Weight: 38.8 kDa
Activity: Measuredby its ability to inhibit rhBMP-4-induced alkaline phosphatase production byATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem.Biophys. Res. Commun. 315:272. The ED50 for this effect istypically 0.5-2 μg/mL in the presence of 75 ng/mL of rhBMP-4.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 76-87kDa, reducing conditions
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Cadm1 cell adhesion molecule 1[ Mus musculus ]
Official Symbol: Cadm1
Synonyms: Cadm1; celladhesion molecule 1; Bl2; ST17; Igsf4; Necl2; RA175; Tslc1; Igsf4a; RA175A;RA175B; RA175C; RA175N; SgIGSF; SynCam; AI987920; 2900073G06Rik;3100001I08Rik; cell adhesion molecule 1; NECL-2; TSLC-1; nectin-like 2;nectin-like protein 2; immunosuperfamily protein Bl2; synaptic cell adhesionmolecule; tumor suppressor in lung cancer 1; immunoglobulin superfamilymember 4; immunoglobulin superfamily member 4A; spermatogenic immunoglobulinsuperfamily; SynCam1
Gene ID: 54725
mRNA Refseq: NM_018770
Protein Refseq: NP_061240
UniProt ID: Q8R5M8
Chromosome Location: 9; 9 B-C
Pathway: Adherens junctionsinteractions; Cell adhesion molecules (CAMs); Cell junction organization;Cell-Cell communication; Nectin/Necl trans heterodimerization
Function: PDZ domain binding;cell adhesion molecule binding; protein C-terminus binding; protein binding;protein homodimerization activity; receptor binding

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