Active Recombinant Mouse Cell Adhesion Molecule 1, His-tagged
Cat.No. : | Cadm1-5604M |
Product Overview : | Recombinant Mouse Cadm1protein was expressed in Murine myeloma cell line with a C-terminal 10-Histag. Ile42-Asp376. |
- Specification
- Gene Information
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Cat. No. : | Cadm1-5604M |
Description : | Cadm1 is a 75 kDaimmunoglobulin superfamily protein that mediates calcium-independent adhesiveinteractions, either homophilic or heterophilic with CRTAM (classI-restricted T cell-associated molecule), Necl1 (SynCAM3) or Nectin3.Alternate names for Cadm1 reflect its activities. As Cadm1, it isdownregulated in onsmall cell lung cancer. This may allow evasion ofantitumor responses, since Cadm1 interaction with CRTAM on activated NK andCD8+ T cells stimulates cytotoxicity and upregulates IFN-γ production. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in PBS. |
N-terminalSequence : | Ile42 |
Molecular Weight : | 38.8 kDa |
Activity : | Measuredby its ability to inhibit rhBMP-4-induced alkaline phosphatase production byATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem.Biophys. Res. Commun. 315:272. The ED50 for this effect istypically 0.5-2 μg/mL in the presence of 75 ng/mL of rhBMP-4. |
Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
SDS-PAGE : | 76-87kDa, reducing conditions |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 100 μg/mL in sterile PBS |
Storage : | Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. |
Gene Name : | Cadm1 cell adhesion molecule 1[ Mus musculus ] |
Official Symbol : | Cadm1 |
Synonyms : | Cadm1; celladhesion molecule 1; Bl2; ST17; Igsf4; Necl2; RA175; Tslc1; Igsf4a; RA175A;RA175B; RA175C; RA175N; SgIGSF; SynCam; AI987920; 2900073G06Rik;3100001I08Rik; cell adhesion molecule 1; NECL-2; TSLC-1; nectin-like 2;nectin-like protein 2; immunosuperfamily protein Bl2; synaptic cell adhesionmolecule; tumor suppressor in lung cancer 1; immunoglobulin superfamilymember 4; immunoglobulin superfamily member 4A; spermatogenic immunoglobulinsuperfamily; SynCam1 |
Gene ID : | 54725 |
mRNA Refseq : | NM_018770 |
Protein Refseq : | NP_061240 |
UniProt ID : | Q8R5M8 |
Chromosome Location : | 9; 9 B-C |
Pathway : | Adherens junctionsinteractions; Cell adhesion molecules (CAMs); Cell junction organization;Cell-Cell communication; Nectin/Necl trans heterodimerization |
Function : | PDZ domain binding;cell adhesion molecule binding; protein C-terminus binding; protein binding;protein homodimerization activity; receptor binding |
Products Types
◆ Recombinant Protein | ||
Cadm1-1931M | Recombinant Mouse Cadm1 Protein, Myc/DDK-tagged | +Inquiry |
CADM1-0282H | Recombinant Human CADM1 Protein, GST-Tagged | +Inquiry |
CADM1-484H | Recombinant Human CADM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CADM1-428H | Recombinant Human CADM1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
CADM1-2260H | Recombinant Human CADM1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
CADM1-2527HCL | Recombinant Human CADM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMutations or genetic variations in CADM1 can lead to altered protein function, potentially contributing to the development of diseases like autism spectrum disorders and various cancers. Studying these variations helps uncover their specific roles in disease progression.
CADM1 is a cell adhesion molecule that plays a crucial role in maintaining tissue integrity and mediating cell-cell adhesion. It is involved in various cellular processes, including tissue development, immune response, and neural cell connectivity.
Post-translational modifications of CADM1, such as phosphorylation and glycosylation, play critical roles in modulating its interactions and functions. Understanding these modifications is important for unraveling disease mechanisms and potential therapeutic targets.
CADM1 mediates immune cell interactions and regulates immune responses. Dysregulation of CADM1 has been implicated in autoimmune diseases like multiple sclerosis, where it affects immune cell adhesion and migration.
Therapeutic strategies targeting CADM1 in cancer treatment include antibody-based therapies and small molecule inhibitors. Challenges include ensuring specificity and minimizing potential side effects, given the diverse roles of CADM1 in different tissues.
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