Recombinant Human Cell Adhesion Molecule 2, His-tagged CADM2-5605H

Recombinant Human Cell Adhesion Molecule 2, His-tagged


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Recombinant Human Cell Adhesion Molecule 2, His-tagged

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Cat. No. : CADM2-5605H
Product Overview : Recombinant Human CADM2protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Ala21-Asp335.
Description : CADM2 is animmunoglobulin super family member that is also designated as synaptic celladhesion molecule 2 and nectin-like protein 3. The four CADM2 proteins,designated A, B, C and D, are type I transmembrane glycoproteins expressedmainly in epithelial cells that contain one V-type Ig-like and two C2-typeIg-like domains in their extracellular regions. These domains arecharacteristically responsible for Ca2+ independent homophilic andheterophilic interactions in the brain, lung, kidney, bladder, prostate andtestis.
Source : Murine myeloma cellline, NS0-derived
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Ala21
Molecular Weight : 35.5 kDa
Activity : Measuredby its ability to enhance neurite outgrowth of E16-E18 rat embryonic corticalneurons. Able to significantly enhance neurite outgrowth when immobilized asa 3 μL droplet containing 50 ng on a nitrocellulose-coated microplate.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 36-55kDa, reducing conditions
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS
Storage : Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : CADM2 cell adhesion molecule 2[ Homo sapiens ]
Official Symbol : CADM2
Synonyms : CADM2; cell adhesionmolecule 2; NECL3; IGSF4D; Necl-3; synCAM2; nectin-like 3; nectin-likeprotein 3; immunoglobulin superfamily member 4D; immunoglobulin superfamily,member 4D; MGC104534; MGC138341; MGC138343; OTTHUMP00000213814;OTTHUMP00000213815; OTTHUMP00000213816; SYNCAM2
Gene ID : 253559
mRNA Refseq : NM_001167674
Protein Refseq : NP_001161146
MIM : 609938
UniProt ID : Q8N3J6
Chromosome Location : 3p12.2
Pathway : Adherens junctionsinteractions; Cell junction organization; Cell-Cell communication; Cell-celljunction organization
Function : adherens junctionorganization; cell junction assembly; cell-cell junction organization

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