"CD207" Related Products


Recombinant Human CD207 Molecule, Langerin, His-tagged

Cat. No.: CD207-5607H
Product Overview: Recombinant Human CD207protein was expressed in Murine myeloma cell line with an N-terminal 9-Histag. Tyr64-Pro328.
Description: CD207 is a type IItransmembrane glycoprotein which is member K of the C type lectin domainfamily 4. CD207 is used as a marker for Langerhans cells (LCs) whichrepresent the immature dendritic cells in the epidermis. LCs uniquely containtennis racket shaped endosomal recycling compartment subdomains withpentalamellar membranes termed Birbeck granules. CD207 is necessary andsufficient for Birbeck granule formation.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: His
Molecular Weight: 31 kDa
Activity: Measuredby its ability to bind biotinylated Mannose-Polyacrylamide in a functionalELISA. Valladeau, J. et al. (2000) Immunity 12:71.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 35-40kDa, reducing conditions
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: CD207 CD207 molecule, langerin[ Homo sapiens ]
Official Symbol: CD207
Synonyms: CD207; CD207molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; CD207antigen, langerin; Langerhans cell specific c-type lectin; C-type lectindomain family 4, member K; Langerin; OTTHUMP00000203299; CD207 antigen
Gene ID: 50489
mRNA Refseq: NM_015717
Protein Refseq: NP_056532
MIM: 604862
UniProt ID: Q9UJ71
Chromosome Location: 2p13
Pathway: Adaptive ImmuneSystem; Antigen processing-Cross presentation; Class I MHC mediated antigenprocessing & presentation; Cross-presentation of soluble exogenousantigens (endosomes); Immune System
Function: binding; mannosebinding; sugar binding

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