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Recombinant Mouse Coxsackie Virus And Adenovirus Receptor

Cat. No.: Cxadr-382M
Product Overview: Recombinantmouse Cxadr protein was expressed in Murine myeloma cellline, NS0-derived. Leu20-Gly237.
Description: Cxadr is a 46 kDatype I transmembrane glycoprotein that belongs to the CTX family of the Igsuperfamily. Cxadr has received attention as a receptor that facilitates genetransfer mediated by most adenoviruses. It is also an adhesion moleculewithin junctional complexes, notably between epithelial cells lining bodycavities and within myocardial intercalated discs.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminal Sequence: Leu20
Molecular Weight: 51.2 kDa
Activity: Measured by theability of the immobilized protein to support the adhesion of humanneutrophils. When 2 x 105 cells/well are added to Cxadr coatedplates (10 μg/mL, 100 μL/well), approximately 40-60% of the cells will adhereafter 20 minutes at 37°C.
Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstitute at 100 ug/mlin sterile PBS.
Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name: Cxadrcoxsackie virus and adenovirus receptor [ Mus musculus ]
Official Symbol: Cxadr
Synonyms: Cxadr; coxsackievirus and adenovirus receptor; CAR; MCAR; MCVADR; AU016810; AW553441;2610206D03Rik; OTTMUSP00000015903; OTTMUSP00000015904; coxsackie virusand adenovirus receptor homolog; Car
Gene ID: 13052
mRNA Refseq: NM_001025192
Protein Refseq: NP_001020363
UniProt ID: P97792
Chromosome Location: 16
Pathway: Adaptive ImmuneSystem; Cell surface interactions at the vascular wall; Hemostasis; ImmuneSystem Immunoregulatory interactions between a Lymphoid and a non-Lymphoidcell Viral; myocarditis
Function: PDZ domain binding;beta-catenin binding; cell adhesion; molecule binding; connexin binding;identical protein binding; protein binding; receptor activity; receptorbinding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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