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Recombinant Mouse Dhh protein

Cat.No. : Dhh-393M
Product Overview : Recombinant Mouse Dhh protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
Source : E.coli
Species : Mouse
Form : Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4, 1 mM DTT, 0.05 % Tween-80.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by murine MC3T3-E1 cells is 5-20 μg/ml.
Molecular Mass : Approximately 20.0 kDa, a single non-glycosylated polypeptide chain containing 177 amino acids.
Protein length : 177
AA Sequence : IIGPGRGPVGRRRYVRKQLVPLLYK QFVPSMPERTLGASGPAEGRVTRGS ERFRDLVPNYNPDIIFKDEENSGAD RLMTERCKERVNALAIAVMNMWPGV RLRVTEGWDEDGHHAQDSLHYEGRA LDITTSDRDRNKYGLLARLAVEAGF DWVYYESRNHIHVSVKADNSLAVRA GG
Endotoxin : Less than 0.1 EU/μg of rMuDHH C23II as determined by LAL method.
Purity : >98% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : Dhh
Official Symbol : Dhh
Synonyms : DHH; desert hedgehog; desert hedgehog protein; HHG-3; C78960; MGC73610;
Gene ID : 13363
mRNA Refseq : NM_007857
Protein Refseq : NP_031883
UniProt ID : Q61488

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does DHH protein deficiency affect reproductive development? 09/30/2022

There is no conclusive evidence that DHH protein deficiency affects the development of the reproductive system, but research suggests that it may be involved in the development of the male reproductive system.

What is the function of DHH protein in the cardiovascular system? 04/27/2022

The function of DHH protein in the cardiovascular system is unknown, but studies suggest that it may be involved in the differentiation and maturation process of cardiomyocytes.

How is DHH protein related to autism? 02/13/2022

Studies have shown that DHH protein may be involved in the development of autism, but the specific mechanism is not clear.

What is the function of DHH protein in the nervous system? 01/31/2021

The function of DHH protein in the nervous system is mainly to promote the differentiation and maturation of neurons, as well as the formation of synapses and the conduction of nerve signals.

Does DHH protein deficiency affect mental development? 09/28/2020

DHH protein deficiency may affect mental development, but the exact extent of the effect needs further research.

How is DHH protein related to arthritis? 06/17/2020

Studies have shown that DHH protein may play an important role in the pathogenesis of arthritis, but its specific role needs to be further studied.

Customer Reviews (3)

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Reviews
08/26/2022

    DHH has good stability under different environmental conditions

    07/18/2021

      DHH plays a significant role in signal transduction pathways.

      04/28/2021

        DHH has good absorbability and high bioavailability.

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