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Recombinant Mouse Fc Receptor, LgG, Alpha Chain Transporter, His-tagged

Cat. No.: Fcgrt-491M
Product Overview: Recombinant Mouse Fcgrtis expressed in Murine myeloma cell line, which has a molecule weight of 32.3kDa. Ser22 ­ Val301, with a C­terminal 6­His tag.
Description: Fc receptor (FCRN) isan approximately 45 kDa transmembrane glycoprotein with structural homology toMHC class I proteins. It is widely expressed in endothelial and epithelial cellsand plays an important role in IgG homeostasis. It does not bind the structurallyrelated chicken IgY. FCRN additionally binds to albumin, and both it and IgG arebound at pH 5.0 but not at pH 8.0. FCRN associates noncovalently with beta 2­Microglobulin,and this interaction is important for the intracellular trafficking of FCRN. FCRNcycles between the plasma membrane and acidified intracellular compartments ofendothelial cells and epithelial cells. It binds endocytosed IgG and albumin inthe low pH vesicles and transports them to the plasma membrane for extracellularrelease at higher Ph. FCRN is also expressed in neutrophils and myeloid antigenpresenting cells. It can enhance IgG­mediated phagocytosis and antigen presentationby these cells, but it promotes the degradation of opsonizing IgG rather thanreturning it to the circulation.
Source: Murine myeloma cell line,NS0­derived
Form: Lyophilized from a 0.2μm filtered solution in PBS, NaCl and Triton.
N-terminal Sequence: Ser22
Molecular Weight: 32.3 kDa
Activity: Measured by its bindingability in a functional ELISA. When Recombinant Mouse FCRN is immobilized at 0.5μg/mL (100 μL/well), the concentration of human IgG that produces 50% of the optimalbinding response is found to be approximately 2 ­ 10 μg/mL.
Purity: >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level: <1.0 EU per 1 μg of the proteinby the LAL method.
Reconstitution: Reconstitute at 250 μg/mL in PBS.
Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol: Fcgrt
Gene Name: Fcgrt Fc receptor, IgG, alpha chaintransporter [ Mus musculus ]
Synonyms: Fcgrt; Fc receptor, IgG,alpha chain transporter; FcRn; FCRN; IgG receptor FcRn large subunit p51; neonatalFc receptor; igG Fc fragment receptor transporter alpha chain; Fc fragment ofIgG, receptor, transporter, alpha; Neonatal Fc receptor; FcRn alpha chain; immunoglobulinreceptor, intestinal, heavy chain; major histocompatibility complex class I-likeFc receptor; neonatal Fc-receptor for Ig
Gene ID: 14132
mRNA Refseq: NM_010189
Protein Refseq: NP_034319
UniProt ID: Q61559
Chromosome Location: 7 B4; 7 23.0 cM
Function: IgG binding; beta-2-microglobulinbinding; receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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