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Active Recombinant Rat Neuropilin 2, His-tagged

Cat.No. : Nrp2-492R
Product Overview : Recombinant Rat Nrp2is expressed in Murine myeloma cell line, which has a molecule weight of 120 kDa. Gln23­ Asp857 (Val809 ­ Asp825 del).
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Cat. No. : Nrp2-492R
Description : Neuropilin­1 (Npn­1,previously known as neuropilin) and Npn­2 (previously known as Npn­1­related molecule)are type I transmembrane proteins that bind members of the class III secretedsemaphorin subfamily which are implicated in repulsive axon guidance. The extracellulardomain of these proteins is composed of two N­terminal CUB (complement­binding)domains (domains a1 and a2), two domains with homology to coagulation factorsV and VIII (domains b1 and b2) and a MAM (meprin) domain (domain c). In the absenceof ligands, neuropilins can form homo­ and hetero­oligomers via hemophilic interactionsof their MAM domains. At the amino acid sequence level, Npn­1and Npn­2 share 44%identity Npn­1 and Npn­2 show different binding specificities for different membersof the semaphorin family. The expression patterns of Npn­1 and Npn­2 in developingneurons of the central and peripheral nervous systems are largely, though notcompletely nonoverlapping.
Source : Mammalian cells
Form : Lyophilized from a 0.2μm filteredsolution in PBS.
N-terminal Sequence : No results obtained:Gln23 predicted
Molecular Weight : 120 kDa
Activity : Measured by its bindingability in a functional ELISA. Immobilized rrNpn­2/Fc Chimera at 5 µg/mL (100µL/well) can bind rhVEGF165 in the presence of 2 µg/mL of heparin with an apparentKd < 1nM.
Purity : >90%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level : <1.0 EU per 1 μg of the proteinby the LAL method.
Reconstitution : Reconstitute at 200 μg/mL in PBS.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol : Nrp2
Gene Name : Nrp2 neuropilin 2 [ Rattus norvegicus]
Synonyms : Nrp2; neuropilin 2; neuropilin-2;vascular endothelial cell growth factor 165 receptor 2; VEGF165R2; VEGF1265R2;NPN2; MGC126574; NP2; PRO27142; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0);receptor for VEGF165 and semaphorins class3; OTTHUMP00000163807; OTTHUMP00000163808;OTTHUMP00000206352; OTTHUMP00000206353; OTTHUMP00000206354; OTTHUMP00000206355
Gene ID : 81527
mRNA Refseq : NM_030869
Protein Refseq : NP_110496
UniProt ID : O35276
Chromosome Location : 9q31
Pathway : Axon guidance; DevelopmentalBiology; L1CAM interactions; Neurophilin interactions with VEGF and VEGFR; NrCAMinteractions; Signal Transduction; Signaling by VEGF; VEGF ligand-receptor interactions
Function : heparin binding; metalion binding; receptor activity; semaphorin receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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