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Recombinant Rat Neuropilin 2, His-tagged

Cat. No.: Nrp2-492R
Product Overview: Recombinant Rat Nrp2is expressed in Murine myeloma cell line, which has a molecule weight of 120 kDa. Gln23­ Asp857 (Val809 ­ Asp825 del).
Description: Neuropilin­1 (Npn­1,previously known as neuropilin) and Npn­2 (previously known as Npn­1­related molecule)are type I transmembrane proteins that bind members of the class III secretedsemaphorin subfamily which are implicated in repulsive axon guidance. The extracellulardomain of these proteins is composed of two N­terminal CUB (complement­binding)domains (domains a1 and a2), two domains with homology to coagulation factorsV and VIII (domains b1 and b2) and a MAM (meprin) domain (domain c). In the absenceof ligands, neuropilins can form homo­ and hetero­oligomers via hemophilic interactionsof their MAM domains. At the amino acid sequence level, Npn­1and Npn­2 share 44%identity Npn­1 and Npn­2 show different binding specificities for different membersof the semaphorin family. The expression patterns of Npn­1 and Npn­2 in developingneurons of the central and peripheral nervous systems are largely, though notcompletely nonoverlapping.
Source: Murine myeloma cell line,NS0­derived
Form: Lyophilized from a 0.2μm filteredsolution in PBS.
N-terminal Sequence: No results obtained:Gln23 predicted
Molecular Weight: 120 kDa
Activity: Measured by its bindingability in a functional ELISA. Immobilized rrNpn­2/Fc Chimera at 5 µg/mL (100µL/well) can bind rhVEGF165 in the presence of 2 µg/mL of heparin with an apparentKd < 1nM.
Purity: >90%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level: <1.0 EU per 1 μg of the proteinby the LAL method.
Reconstitution: Reconstitute at 200 μg/mL in PBS.
Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol: Nrp2
Gene Name: Nrp2 neuropilin 2 [ Rattus norvegicus]
Synonyms: Nrp2; neuropilin 2; neuropilin-2;vascular endothelial cell growth factor 165 receptor 2; VEGF165R2; VEGF1265R2;NPN2; MGC126574; NP2; PRO27142; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0);receptor for VEGF165 and semaphorins class3; OTTHUMP00000163807; OTTHUMP00000163808;OTTHUMP00000206352; OTTHUMP00000206353; OTTHUMP00000206354; OTTHUMP00000206355
Gene ID: 81527
mRNA Refseq: NM_030869
Protein Refseq: NP_110496
UniProt ID: O35276
Chromosome Location: 9q31
Pathway: Axon guidance; DevelopmentalBiology; L1CAM interactions; Neurophilin interactions with VEGF and VEGFR; NrCAMinteractions; Signal Transduction; Signaling by VEGF; VEGF ligand-receptor interactions
Function: heparin binding; metalion binding; receptor activity; semaphorin receptor activity

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