Active Recombinant Human Fucosidase, Alpha-L- 1, Tissue, His-tagged
Cat.No. : | FUCA1-471H |
Product Overview : | Recombinant Human FUCA1protein was expressed in Murine myeloma cell line with an N-terminal CD33 signalsequence and a C-terminal 6-His tag. Gln32-Lys466. |
- Specification
- Gene Information
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Cat. No. : | FUCA1-471H |
Description : | Fucosylated glycoconjugatesplay numerous roles in biological processes, such as development, apoptosis andthe immune responses, and are involved in the pathology of inflammation, cancerand cystic fibrosis. Tissue α LFucosidase, also known as FUCA1, is a lysosomalenzyme responsible for hydrolyzing αLfucose moieties from glycolipids and oligosaccharides. |
Source : | Mammalian cells |
Form : | Supplied as a 0.2 μmfiltered solution in Tris and NaCl. |
N-terminalSequence : | Gln32 |
Molecular Weight : | 51 kDa |
Activity : | Measuredby its ability to cleave a fluorogenic substrate 4-methylumbelliferyl-α-L-fucopyranoside.The specific activity is > 4800 pmol/min/μg, as measured under the describedconditions. See Activity Assay Protocol. |
Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Bluestain at 5 μg per lane. |
Storage : | Use a manualdefrost freezer and avoid repeated freezethaw cycles. 6 months from date of receipt,20 to 70 °C as supplied. 3 months, 20 to 70°C under sterile conditions after opening. |
Gene Name : | FUCA1 fucosidase, alpha-L- 1, tissue[ Homo sapiens ] |
Official Symbol : | FUCA1 |
Synonyms : | FUCA1; fucosidase,alpha-L- 1, tissue; FUCA; tissue alpha-L-fucosidase; alpha-L-fucosidase 1; alpha-L-fucosidaseI; alpha-L-fucoside fucohydrolase 1; EC 3.2.1.51; Nbla10230 |
Gene ID : | 2517 |
mRNA Refseq : | NM_000147 |
Protein Refseq : | NP_000138 |
MIM : | 612280 |
UniProt ID : | P04066 |
Chromosome Location : | 1p34 |
Pathway : | Lysosome; Other glycandegradation |
Function : | alpha-L-fucosidase activity;cation binding; hydrolase activity; sugar bindin |
Products Types
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FUCA1-1217M | Recombinant Mouse FUCA1 Protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
FUCA1-1212HCL | Recombinant Human FUCA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGenetic mutations in FUCA1 can lead to deficient enzyme activity, affecting glycan metabolism.
Altered FUCA1 activity is associated with lysosomal storage diseases, such as fucosidosis, due to the accumulation of undigested glycans.
FUCA1, an alpha-L-fucosidase, is involved in the breakdown of complex sugars (glycans) in cellular metabolism.
FUCA1 is crucial for normal lysosomal function, aiding in the breakdown of glycoproteins and glycolipids.
It helps in glycan degradation by cleaving fucose residues, a key step in glycan processing.
FUCA1 works alongside other enzymes in glycan metabolism, ensuring efficient breakdown and recycling of cellular components.
Targeting FUCA1 could offer therapeutic strategies for treating lysosomal storage disorders and related metabolic conditions.
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