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Active Recombinant Human Fucosidase, Alpha-L- 1, Tissue, His-tagged

Cat.No. : FUCA1-471H
Product Overview : Recombinant Human FUCA1protein was expressed in Murine myeloma cell line with an N-terminal CD33 signalsequence and a C-terminal 6-His tag. Gln32-Lys466.
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Cat. No. : FUCA1-471H
Description : Fucosylated glycoconjugatesplay numerous roles in biological processes, such as development, apoptosis andthe immune responses, and are involved in the pathology of inflammation, cancerand cystic fibrosis. Tissue α LFucosidase, also known as FUCA1, is a lysosomalenzyme responsible for hydrolyzing αLfucose moieties from glycolipids and oligosaccharides.
Source : Mammalian cells
Form : Supplied as a 0.2 μmfiltered solution in Tris and NaCl.
N-terminalSequence : Gln32
Molecular Weight : 51 kDa
Activity : Measuredby its ability to cleave a fluorogenic substrate 4-methylumbelliferyl-α-L-fucopyranoside.The specific activity is > 4800 pmol/min/μg, as measured under the describedconditions. See Activity Assay Protocol.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Bluestain at 5 μg per lane.
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 6 months from date of receipt,20 to 70 °C as supplied. 3 months, 20 to 70°C under sterile conditions after opening.
Gene Name : FUCA1 fucosidase, alpha-L- 1, tissue[ Homo sapiens ]
Official Symbol : FUCA1
Synonyms : FUCA1; fucosidase,alpha-L- 1, tissue; FUCA; tissue alpha-L-fucosidase; alpha-L-fucosidase 1; alpha-L-fucosidaseI; alpha-L-fucoside fucohydrolase 1; EC 3.2.1.51; Nbla10230
Gene ID : 2517
mRNA Refseq : NM_000147
Protein Refseq : NP_000138
MIM : 612280
UniProt ID : P04066
Chromosome Location : 1p34
Pathway : Lysosome; Other glycandegradation
Function : alpha-L-fucosidase activity;cation binding; hydrolase activity; sugar bindin

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do genetic variations in FUCA1 affect its enzymatic activity? 12/10/2022

Genetic mutations in FUCA1 can lead to deficient enzyme activity, affecting glycan metabolism.

What is the impact of altered FUCA1 activity on lysosomal storage diseases? 02/27/2022

Altered FUCA1 activity is associated with lysosomal storage diseases, such as fucosidosis, due to the accumulation of undigested glycans.

What is the primary role of FUCA1 in cellular metabolism? 02/28/2021

FUCA1, an alpha-L-fucosidase, is involved in the breakdown of complex sugars (glycans) in cellular metabolism.

What role does FUCA1 play in lysosomal function? 10/22/2020

FUCA1 is crucial for normal lysosomal function, aiding in the breakdown of glycoproteins and glycolipids.

How does FUCA1 contribute to glycan breakdown? 08/26/2018

It helps in glycan degradation by cleaving fucose residues, a key step in glycan processing.

How does FUCA1 interact with other enzymes in glycan metabolism? 06/27/2018

FUCA1 works alongside other enzymes in glycan metabolism, ensuring efficient breakdown and recycling of cellular components.

What potential therapeutic applications arise from targeting FUCA1 in metabolic disorders? 06/05/2017

Targeting FUCA1 could offer therapeutic strategies for treating lysosomal storage disorders and related metabolic conditions.

Customer Reviews (3)

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Reviews
08/16/2021

    Precise results, a trusted partner in our experiments.

    05/11/2020

      Dependable service, vital for accurate protein analysis.

      09/12/2019

        Efficient support, accelerates our research progress.

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