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Recombinant Human Aldehyde Dehydrogenase 3 Family, Member B2, GST-tagged

Cat.No. : ALDH3B2-497H
Product Overview : RecombinantHuman ALDH3B2 protein was expressed as GST-tagged fusion proteins by E. coli andpurified by GSH-sepharose. The purified ALDH3B2 was resolved in 1M PBS (58mMNa2HPO4, 17mM NaH2PO4, 68mM NaCl,pH8) added with 100mM GSH and 1% Triton X-100, 15% glycerol.
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Cat. No. : ALDH3B2-497H
Description : Aldehydedehydrogenase family 3 member B2 is an enzyme that in humans is encoded bythe ALDH3B2 gene. This gene encodes a member of the aldehyde dehydrogenasefamily, a group of isozymes that may play a major role in the detoxificationof aldehydes generated by alcohol metabolism and lipid peroxidation. The geneof this particular family member is over 10 kb in length. The expression ofthese transcripts is restricted to the salivary gland among the human tissuesexamined. Alternate transcriptional splice variants have been characterized.
Host : E. coli.
Antigen Peptide : 92-385aa
Full Length : False
Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8) added with 100mM GSH and 1%Triton X-100, 15% glycerol.
Storage : Theprotein is stored in PBS at -20°C. Repeatedfreeze-thaw cycles should be avoided.
Gene Name : ALDH3B2 aldehyde dehydrogenase 3family, member B2 [ Homo sapiens ]
Official Symbol : ALDH3B2
Synonyms : ALDH3B2; aldehyde dehydrogenase3 family, member B2; ALDH8; aldehyde dehydrogenase family 3 member B2;OTTHUMP00000235616; aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8;EC1.2.1.5; EC1.2.1
Gene ID : 222
mRNA Refseq : NM_000695
Protein Refseq : NP_000686
MIM : 601917
UniProt ID : P48448
Chromosome Location : 11q13
Pathway : Drug metabolism-cytochromeP450; Glycolysis / Gluconeogenesis; Histidine metabolism; Metabolicpathways; metabolism of xenobiotics by cytochromeP450; Phenylalanine metabolism; Tyrosine metabolism; beta-Alaninemetabolism
Function : 3-chloroallyl aldehyde dehydrogenase activity; aldehydedehydrogenase [NAD(P)+] activity; oxidoreductase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Is there any evidence linking ALDH3B2 to cancer? 12/24/2022

Currently, there is limited research connecting ALDH3B2 specifically to cancer. However, dysregulated expression or activity of other ALDH family members has been implicated in various cancers, including breast, lung, liver, and prostate cancer. Since ALDH3B2 belongs to the same enzyme family, it is plausible that it may play a role in cancer development or progression. Further studies are needed to investigate the potential involvement of ALDH3B2 in cancer biology.

Has ALDH3B2 been studied in cancer biology or tumor development? 11/25/2022

Currently, there is limited research on the involvement of ALDH3B2 in cancer biology or tumor development. ALDH enzymes, in general, have been extensively studied in the context of cancer stem cells and their potential role in tumor initiation and progression. However, ALDH3B2 has not received as much attention in the field. It remains to be determined if ALDH3B2 plays a significant role in tumor development or has any implications in cancer biology.

Is there any evidence linking ALDH3B2 to oxidative stress or antioxidant defense? 09/22/2022

Limited studies have explored the potential involvement of ALDH3B2 in oxidative stress or antioxidant defense. It is known that certain ALDH family members are involved in cellular protection against oxidative stress by metabolizing reactive aldehydes generated during oxidative damage. However, the specific role of ALDH3B2 in these processes is not well-understood. Additional research is necessary to determine the association between ALDH3B2 and oxidative stress or antioxidant defense mechanisms.

Is ALDH3B2 implicated in any metabolic pathways? 06/20/2022

The exact metabolic pathways involving ALDH3B2 are not yet known. However, as a member of the ALDH enzyme family, it is likely involved in metabolic processes related to aldehyde oxidation or detoxification. ALDH enzymes play important roles in the metabolism of several compounds, including aldehydes derived from lipid peroxidation, alcohol metabolism, and xenobiotic detoxification. ALDH3B2 may function in similar pathways, but further investigations are necessary to identify and elucidate its specific metabolic pathways and substrates.

Are there any genetic variants or mutations in ALDH3B2 associated with disease? 05/15/2022

There is limited information available regarding genetic variants or mutations in ALDH3B2 and their association with disease. However, some studies have reported single nucleotide polymorphisms (SNPs) in the ALDH3B2 gene in certain populations, suggesting potential genetic variations. However, the functional implications of these variants and their association with specific diseases remain largely unknown and require further investigation.

Are there any drugs or compounds known to modulate the expression or activity of ALDH3B2? 07/23/2021

As of now, no specific drugs or compounds have been identified to modulate the expression or activity of ALDH3B2. However, ALDH enzymes, in general, have been targeted by certain drugs, such as disulfiram, which inhibits ALDH activity and is utilized in the treatment of alcohol dependency. Further research is needed to investigate if there are specific compounds or drugs that can modulate the expression or activity of ALDH3B2 and assess their therapeutic potential.

Is ALDH3B2 protein involved in any specific biological pathways or processes? 10/28/2020

The specific biological pathways or processes in which ALDH3B2 protein is involved are not well-characterized. ALDH3B2 belongs to the aldehyde dehydrogenase (ALDH) enzyme family, which generally plays a role in the metabolism of aldehydes. However, the exact functions and substrates of ALDH3B2 are not extensively studied or understood.

Are there any animal models or cell lines available to study ALDH3B2? 04/21/2020

As of now, there are no specific animal models or cell lines available that have been developed specifically to study ALDH3B2. Animal models and cell lines are valuable tools for understanding gene function and studying the mechanisms of diseases. However, the lack of available models or cell lines for ALDH3B2 limits our ability to investigate its role in vivo or in a controlled laboratory setting. Future research efforts may focus on developing relevant models or cell lines to facilitate the study of ALDH3B2.

Can ALDH3B2 be used as a therapeutic target for any diseases? 02/08/2020

Currently, there is insufficient evidence to support the use of ALDH3B2 as a therapeutic target for any diseases. Since the function and role of ALDH3B2 are not well-characterized, it is challenging to discern its potential therapeutic applications. Further research is necessary to determine if ALDH3B2 could serve as a feasible therapeutic target and to explore its potential implications in disease treatment.

Can ALDH3B2 be used as a diagnostic or prognostic marker in diseases? 08/01/2019

Limited information is available on the diagnostic or prognostic value of ALDH3B2 in diseases. Since ALDH enzymes, including ALDH3B2, are involved in various cellular processes, dysregulation of ALDH3B2 may have implications in disease progression or prognosis. However, further research is needed to assess the potential of ALDH3B2 as a biomarker in specific diseases.

Are there any functional studies that explore the enzymatic activity of ALDH3B2? 10/03/2018

Currently, there is a lack of functional studies specifically investigating the enzymatic activity of ALDH3B2. While ALDH enzymes, in general, are known to catalyze the oxidation of aldehydes to their corresponding carboxylic acids, the specific substrates and catalytic properties of ALDH3B2 have not been extensively characterized. Functional studies, such as enzymatic assays using purified ALDH3B2 protein or cell-based assays, are needed to determine the substrate specificity and activity of ALDH3B2.

Have there been any studies investigating the expression of ALDH3B2 in different tissues or cells? 09/28/2018

Limited studies have explored the expression of ALDH3B2 in different tissues or cells. However, some publicly available databases, such as the Genotype-Tissue Expression (GTEx) project, provide gene expression data across various human tissues. According to GTEx data, ALDH3B2 is expressed at relatively low levels in multiple tissues, including the skin, esophagus, bladder, and cervix, among others.

What are the functional consequences of ALDH3B2 dysregulation? 07/25/2018

The functional consequences of ALDH3B2 dysregulation are not well-understood due to limited research on this specific enzyme. However, dysregulation of other ALDH family members has been associated with various pathophysiological processes, including cancer progression, drug resistance, oxidative stress, and metabolic disorders.

Can the expression of ALDH3B2 be regulated under certain conditions or stimuli? 05/04/2018

Limited studies have investigated the regulation of ALDH3B2 expression under specific conditions or stimuli. However, it is well-known that the expression of several ALDH family members can be regulated by different factors, such as oxidative stress, hormones, and environmental toxins. Since ALDH3B2 belongs to the same enzyme family, it is reasonable to speculate that its expression may also be modulated by similar factors. However, more research is needed to determine the precise conditions or stimuli that can regulate the expression of ALDH3B2.

Are there any knockout or knockdown studies of ALDH3B2 to elucidate its function? 04/30/2018

Currently, there is a lack of specific knockout or knockdown studies focusing on ALDH3B2 to elucidate its function. Most research on ALDH3B2 is limited to exploring its gene expression patterns or analyzing genetic variants associated with certain diseases. Knockout or knockdown studies would be valuable in examining the functional consequences of ALDH3B2 depletion and providing insights into its role in cellular processes. However, further studies are needed to investigate ALDH3B2's function through these experimental approaches.

Are there any therapeutic strategies targeting ALDH3B2? 08/26/2017

Currently, there are no specific therapeutic strategies targeting ALDH3B2. However, strategies aimed at modulating ALDH enzyme activity in general have been explored for potential therapeutic applications. Since ALDH3B2 is a member of the ALDH family, therapies targeting ALDH enzymes may indirectly impact ALDH3B2 activity. Nevertheless, more research is required to develop targeted therapies specifically directed at ALDH3B2.

Are there any genetic variants or mutations in the ALDH3B2 gene associated with diseases? 12/17/2016

Research on genetic variants or mutations specifically within the ALDH3B2 gene is limited, and no significant associations with diseases have been reported to date. However, some studies have identified genetic variants in the broader ALDH gene family that are associated with various diseases, such as alcohol dependence, cancer susceptibility, and cardiovascular disorders. Further investigations are needed to determine if specific genetic variants or mutations in ALDH3B2 are implicated in disease susceptibility or have functional effects.

Does ALDH3B2 have any known interacting proteins or partners? 06/27/2016

The known interacting proteins or partners of ALDH3B2 have not been extensively characterized. However, interaction studies of other ALDH family members have identified several potential binding partners involved in various cellular processes, such as detoxification, metabolism, and signal transduction. It is possible that ALDH3B2 may interact with similar proteins, but more research is needed to identify and characterize its binding partners.

Are there any known inhibitors or activators of ALDH3B2? 03/05/2016

Currently, there are no known specific inhibitors or activators of ALDH3B2. However, it is possible that compounds targeting other ALDH family members may also affect ALDH3B2 activity to some extent. Further research is needed to identify specific modulators of ALDH3B2 enzyme activity.

Customer Reviews (3)

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Reviews
05/08/2022

    Their support has been invaluable in troubleshooting and providing efficient solutions, enhancing the overall efficiency and productivity of my experiments.

    09/28/2021

      With its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.

      07/10/2016

        Their knowledgeable and responsive team has consistently demonstrated their ability to address any concerns or challenges I have encountered along the way.

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