Recombinant Human SNIP1, His-tagged

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Recombinant Human SNIP1, His-tagged

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Cat. No. : SNIP1-3537H
Product Overview : Recombinant humanSNIP1 protein, fused to His-tag at N-terminus, was expressed in E. coliand purified by using conventional chromatography techniques.
Description : SNIP1is smad nuclear interacting protein contains a forkhead-associated (FHA)domain and acts as a nuclear inhibitor of CBP/p300. This protein is aninhibitor of the TGF-beta signal transduction pathway and to be important insuppressing transcriptional activation dependent on the co-activators CBP andp300. Inhibition of NF-kappa B activity is a function of the N-terminaldomain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit,RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smadsignaling by SNIP1.
Application : SDS-PAGE
Form : Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 100mM NaCl.
Molecular Weight : 18.8 kDa (160aa),confirmed by MALDI-TOF
Purity : > 90% by SDS-PAGE
Concentration : 1 mg/ml(determined by Bradford assay)
Sequences of aminoacids : MGSSHHHHHH SSGLVPRGSH MYIIDLGSGNGTFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDSRWRLYPFKNDEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol : SNIP1
Gene Name : SNIP1 Smad nuclear interacting protein1 [ Homo sapiens ]
Synonyms : SNIP1; Smad nuclear interacting protein1; FLJ12553; dJ423B22.2; RP3-423B22.3; smadnuclear-interacting protein 1; FHAdomain-containing protein SNIP1; Smadnuclear interacting protein (SNIP1); OTTHUMP00000004404
Gene ID : 79753
mRNA Refseq : NM_024700
Protein Refseq : NP_078976
MIM : 608241
UniProt ID : Q8TAD8
Chromosome Location : 1p34.3
Pathway : Regulation of nuclear SMAD2/3signaling; TGF-beta Receptor Signaling Pathway
Function : Protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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