Recombinant Human TOP2B protein, GST-tagged
Cat.No. : | TOP2B-6942H |
Product Overview : | Recombinant Human TOP2B(1411 a.a. - 1523 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ. |
- Specification
- Gene Information
- Related Products
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 38.17 kDa |
Applications : | Applications Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | TOP2B topoisomerase (DNA) II beta 180kDa [ Homo sapiens ] |
Official Symbol : | TOP2B |
Synonyms : | TOP2B; topoisomerase (DNA) II beta 180kDa; topoisomerase (DNA) II beta (180kD); DNA topoisomerase 2-beta; topo II beta; antigen MLAA-44; topoisomerase IIb; topoisomerase II beta; U937 associated antigen; DNA topoisomerase II beta; DNA topoisomerase II, 180 kD; DNA topoisomerase II, beta isozyme; TOPIIB; top2beta; |
Gene ID : | 7155 |
mRNA Refseq : | NM_001068 |
Protein Refseq : | NP_001059 |
MIM : | 126431 |
UniProt ID : | Q02880 |
Chromosome Location : | 3p24 |
Function : | ATP binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA-dependent ATPase activity; chromatin binding; enzyme binding; histone deacetylase binding; isomerase activity; nucleotide binding; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (5)
Ask a questionTOP2B is crucial for chromosome segregation, transcription, and DNA recombination, playing a central role in maintaining genomic stability.
TOP2B helps in remodeling chromatin by resolving supercoils, influencing the accessibility of DNA for various cellular processes.
Increased expression of TOP2B has been associated with resistance to certain chemotherapeutic agents, impacting the efficacy of cancer treatments.
Mutations in TOP2B can lead to impaired DNA repair, genomic instability, and increased susceptibility to various diseases, including certain types of cancer.
Various factors, including cell cycle progression and response to DNA damage, influence the expression of TOP2B to meet the dynamic needs of the cell.
Customer Reviews (3)
Write a reviewThe quality of this product exceeded my expectations, providing precise and reliable results in our experiments.
Rapid delivery! Ordered and received the product within a short timeframe, allowing us to proceed with our experiments without delays.
Exceptional service!
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