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Recombinant Human TOP2B protein, GST-tagged

Cat.No. : TOP2B-6942H
Product Overview : Recombinant Human TOP2B(1411 a.a. - 1523 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
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  • Gene Information
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Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 38.17 kDa
Applications : Applications Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : TOP2B topoisomerase (DNA) II beta 180kDa [ Homo sapiens ]
Official Symbol : TOP2B
Synonyms : TOP2B; topoisomerase (DNA) II beta 180kDa; topoisomerase (DNA) II beta (180kD); DNA topoisomerase 2-beta; topo II beta; antigen MLAA-44; topoisomerase IIb; topoisomerase II beta; U937 associated antigen; DNA topoisomerase II beta; DNA topoisomerase II, 180 kD; DNA topoisomerase II, beta isozyme; TOPIIB; top2beta;
Gene ID : 7155
mRNA Refseq : NM_001068
Protein Refseq : NP_001059
MIM : 126431
UniProt ID : Q02880
Chromosome Location : 3p24
Function : ATP binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA-dependent ATPase activity; chromatin binding; enzyme binding; histone deacetylase binding; isomerase activity; nucleotide binding; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What cellular processes does TOP2B participate in, besides replication? 01/14/2022

TOP2B is crucial for chromosome segregation, transcription, and DNA recombination, playing a central role in maintaining genomic stability.

How does TOP2B contribute to the regulation of chromatin structure? 06/18/2021

TOP2B helps in remodeling chromatin by resolving supercoils, influencing the accessibility of DNA for various cellular processes.

What is the relationship between TOP2B and drug resistance in cancer treatment? 04/07/2020

Increased expression of TOP2B has been associated with resistance to certain chemotherapeutic agents, impacting the efficacy of cancer treatments.

What is the consequence of TOP2B mutations on cellular function? 08/22/2019

Mutations in TOP2B can lead to impaired DNA repair, genomic instability, and increased susceptibility to various diseases, including certain types of cancer.

How is TOP2B expression regulated in cells? 11/03/2018

Various factors, including cell cycle progression and response to DNA damage, influence the expression of TOP2B to meet the dynamic needs of the cell.

Customer Reviews (3)

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Reviews
01/08/2022

    The quality of this product exceeded my expectations, providing precise and reliable results in our experiments.

    09/25/2019

      Rapid delivery! Ordered and received the product within a short timeframe, allowing us to proceed with our experiments without delays.

      04/18/2018

        Exceptional service!

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