Native Mouse Myelin basic protein

• Cat.No.: MBP-6949M
• Product Overview: Purified from mouse central nervous system tissue.

Specification

• Description: MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
• Source: mouse central nervous system tissue
• Species: Mouse
• Form: Lyophilized. Essentially salt-free.
• Purity: ≥95% (SDS-PAGE; immunoblot)
• Stability: Stable for at least 1 year when stored at +4 centigrade. Reconstituted protein is stable for at least six months at -20 centigrade and for at least 24h at +37 centigrade in aqueous solution.
• Storage: Short Term Storage: +4 centigrade; Long Term Storage: -20 centigrade.
• Reconstitution: Reconstitute with distilled water.
• Publication:
  Induction of broadly reactive influenza antibodies increases susceptibility to autoimmunity (2022)

Gene Information

• Gene Name: Mbp myelin basic protein [ Mus musculus ]
• Official Symbol: MBP
• Synonyms: MBP; myelin basic protein; Golli-Mbp; myelin basic protein; shiverer; myelin deficient; myelin A1 protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp
• Gene ID: 17196
• mRNA Refseq: NM_001025245
• Protein Refseq: NP_001020416
• Pathway: MAPK Cascade, organism-specific biosystem
• Function: protease binding; structural constituent of myelin sheath