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Recombinant Human TLR4, GST-tagged

Cat.No. : TLR4-291H
Product Overview : HumanTLR4 partial ORF (130 aa-201 aa) recombinant protein fused with a GST-tag atN-terminal was expressed in wheat germ.
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  • Gene Information
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Cat. No. : TLR4-291H
Description : The protein encoded by this gene is a member of the Toll-likereceptor (TLR) family which plays a fundamental role in pathogen recognitionand activation of innate immunity. TLRs are highly conserved from Drosophilato humans and share structural and functional similarities. They recognizepathogen-associated molecular patterns (PAMPs) that are expressed oninfectious agents, and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibit different patternsof expression. This receptor is most abundantly expressed in placenta, and inmyelomonocytic subpopulation of the leukocytes. It has been implicated insignal transduction events induced by lipopolysaccharide (LPS) found in mostgram-negative bacteria. Mutations in this gene have been associated withdifferences in LPS responsiveness. Also, several transcript variants of thisgene have been found, but the protein coding potential of most of them isuncertain.
Source : wheat germ
Form : 50mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Weight : 33.55kDa
Purification : GlutathioneSepharose 4 Fast Flow
Sequences of aminoacids : KLVAVETNLASLENFPIGHLKTLKE LNVAHNLIQSFKLPEYFSNLTNLEH LDLSSNKIQSIYCTDLRVLHQM
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Gene Name : TLR4 toll-like receptor 4 [ Homo sapiens]
Official Symbol : TLR4
Synonyms : TLR4; toll-like receptor 4; TOLL; CD284; TLR-4; ARMD10; toll-like receptor 4; hToll; homolog of Drosophila toll; CD284antigen; OTTHUMP00000022807
Gene ID : 7099
mRNA Refseq : NM_003266
Protein Refseq : NP_003257
MIM : 603030
UniProt ID : O00206
Chromosome Location : 9q33.1
Pathway : Activated TLR4 signalling; Amoebiasis; IKK complex recruitmentmediated by RIP1; Immune System; Influenza A; Innate Immune System; Leishmaniasis;MyD88 cascade initiated on plasma membrane; Pathogenic Escherichia coliinfection; Pertussis; Rheumatoid arthritis; TRAF6 mediated induction of TAK1complex; Toll Like Receptor 10 (TLR10) Cascade; Toll Like Receptor 2 (TLR2)Cascade; Toll Receptor Cascades; Toll-like receptor signaling pathway
Function : lipopolysaccharide binding; lipopolysaccharide receptor activity;phosphatidylinositol 3-kinase binding; protein binding; receptor activity; embranesignaling receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TLR4 signaling intersect with the nuclear factor-kappa B (NF-κB) pathway? 11/20/2021

TLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.

Can you explain the molecular events following TLR4 activation upon ligand binding? 08/14/2020

Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.

What is the role of the TLR4 signaling pathway in innate immunity? 02/18/2019

The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.

Can you elaborate on the crosstalk between TLR4 and other pattern recognition receptors (PRRs)? 10/02/2018

TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.

Can you describe the molecular structure of TLR4 and its functional domains? 04/23/2018

TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.

Customer Reviews (3)

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Reviews
12/29/2020

    Precision in every experiment—this product is a game-changer for us.

    04/07/2019

      Timely delivery is key, and this product arrived on schedule.

      08/06/2018

        Exceptional customer service—knowledgeable staff guided us through the selection process.

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