Recombinant Human TLR4, GST-tagged
Cat.No. : | TLR4-291H |
Product Overview : | HumanTLR4 partial ORF (130 aa-201 aa) recombinant protein fused with a GST-tag atN-terminal was expressed in wheat germ. |
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- Gene Information
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Cat. No. : | TLR4-291H |
Description : | The protein encoded by this gene is a member of the Toll-likereceptor (TLR) family which plays a fundamental role in pathogen recognitionand activation of innate immunity. TLRs are highly conserved from Drosophilato humans and share structural and functional similarities. They recognizepathogen-associated molecular patterns (PAMPs) that are expressed oninfectious agents, and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibit different patternsof expression. This receptor is most abundantly expressed in placenta, and inmyelomonocytic subpopulation of the leukocytes. It has been implicated insignal transduction events induced by lipopolysaccharide (LPS) found in mostgram-negative bacteria. Mutations in this gene have been associated withdifferences in LPS responsiveness. Also, several transcript variants of thisgene have been found, but the protein coding potential of most of them isuncertain. |
Source : | wheat germ |
Form : | 50mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Weight : | 33.55kDa |
Purification : | GlutathioneSepharose 4 Fast Flow |
Sequences of aminoacids : | KLVAVETNLASLENFPIGHLKTLKE LNVAHNLIQSFKLPEYFSNLTNLEH LDLSSNKIQSIYCTDLRVLHQM |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | TLR4 toll-like receptor 4 [ Homo sapiens] |
Official Symbol : | TLR4 |
Synonyms : | TLR4; toll-like receptor 4; TOLL; CD284; TLR-4; ARMD10; toll-like receptor 4; hToll; homolog of Drosophila toll; CD284antigen; OTTHUMP00000022807 |
Gene ID : | 7099 |
mRNA Refseq : | NM_003266 |
Protein Refseq : | NP_003257 |
MIM : | 603030 |
UniProt ID : | O00206 |
Chromosome Location : | 9q33.1 |
Pathway : | Activated TLR4 signalling; Amoebiasis; IKK complex recruitmentmediated by RIP1; Immune System; Influenza A; Innate Immune System; Leishmaniasis;MyD88 cascade initiated on plasma membrane; Pathogenic Escherichia coliinfection; Pertussis; Rheumatoid arthritis; TRAF6 mediated induction of TAK1complex; Toll Like Receptor 10 (TLR10) Cascade; Toll Like Receptor 2 (TLR2)Cascade; Toll Receptor Cascades; Toll-like receptor signaling pathway |
Function : | lipopolysaccharide binding; lipopolysaccharide receptor activity;phosphatidylinositol 3-kinase binding; protein binding; receptor activity; embranesignaling receptor activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.
Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.
The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.
TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.
TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.
Customer Reviews (3)
Write a reviewPrecision in every experiment—this product is a game-changer for us.
Timely delivery is key, and this product arrived on schedule.
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