Recombinant Human ABCB1, His-tagged ABCB1-2549H

Recombinant Human ABCB1, His-tagged


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Recombinant Human ABCB1, His-tagged

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Cat. No. : ABCB1-2549H
Product Overview : The protein was expressed as 6*his-tagged fusion protein by E. coli and Purified by Ni-sepharose.
Description : The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Source : E. coli
Antigen PeptideRegion : 624-708aa
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.0) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Storage : The protein is stored in PBS buffer at -20°C. Repeated freeze-thaw cycles should be avoided.
Gene Name : ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 [ Homo sapiens ]
Official Symbol : ABCB1
Synonyms : ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MGC163296; multidrug resistance protein 1; P-glycoprotein 1;colchicin sensitivity; doxorubicin resistance; EC
Gene ID : 5243
mRNA Refseq : NM_000927
Protein Refseq : NP_000918
MIM : 171050
UniProt ID : P08183
Chromosome Location : 7q21.12
Pathway : ABC transporters; ABC-family proteins mediated transport; Bile secretion; Codeine and morphine metabolism; HIF-1-alpha transcription factor network; Nuclear receptors in lipid metabolism and toxicity; Transmembrane transport of small molecules
Function : ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; hydrolase activity; nucleotide binding; protein binding; transporter activity; xenobiotic-transporting ATPase activity

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