Recombinant Human BMP6


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Recombinant Human BMP6

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Cat. No. : BMP6-68H
Product Overview : Recombinant human bone morphogenetic protein 6 (Gln382-His513) was expressed in NSO Cells.
Description : Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. Human BMP-6 is synthesized as a 513 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 18 kDa C-terminal mature protein. Biologically active BMP -6 consists of a disulfide-linked homodimer of the mature proteins. Mature human BMP-6 shares 96% and 98% aa sequence identity with mouse and rat BMP-6, respectively. Cellular responses to BMP-6 are mediated by hetero-oligomeric complexes of type I (Activin RIA/ALK -2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) serine/threonine kinase receptors. Glycosylation of BMP-6 is required for its interaction with Activin RIA. BMP6 induces the expression of Noggin and is subsequently antagonized by Noggin. BMP-6 induces a wide range of cellular responses. It promotes osteoblast differentiation from mesenchymal stem cells, chondrocyte maturation (9), Ang II-induced aldosterone production in the adrenal cortex, hormone production and responsiveness in ovarian granulosa cells, iNOS and TNF-α production in macrophages, the cell death of B cells, and neurite outgrowth. BMP-6 expression is induced in astrocytes surrounding sites of brain injury where it functions as a neuroprotectant. BMP-6 is up-regulated during prostate cancer progression and promotes tumor cell metastasis to bone. Through interactions with the BMP coreceptor RGM-C/Hemojuvelin, BMP-6 plays an important role in iron homeostasis by promoting Hepcidin expression and preventing serum iron overload.
Source : Mouse NSO Cells
Sequence : Gln382-His 513
SDS-PAGE : 18 kDa, reducing conditions
Activity : Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.02-0.15 μg/mL.
Endotoxin Level : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Formulation : Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. See Certificate of Analysis for details.
Reconstitution : Reconstitute at 100 μg/mL in sterile 4 mMHCl containing at least 0.1% human or bovine serum albumin.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability &Storage : Use a manual defrost freezer and avoid repeated freeze/thaw cycles. 12 months from date of receipt, 20 to 70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, 20 to 70 °C under sterile conditions after reconstitution.
Rendering based on PDB 2QCW. :

Gene Name : BMP6 bone morphogenetic protein 6 [ Homo sapiens ]
Official Symbol : BMP6
Synonyms : BMP6; bone morphogenetic protein 6; VGR; VG; vegetal related growth factor (TGFB-related); Bone morphogenetic protein 6; VG-1-related protein; VG-1-R; VGR-1
Gene ID : 654
mRNA Refseq : NM_001718
Protein Refseq : NP_001709
MIM : 112266
UniProt ID : P22004
Chromosome Location : 6p24-p23
Pathway : Cytokine-cytokine receptor interaction; Hedgehog signaling pathway; TGF-beta signaling pathway.
Function : cytokine activity; growth factor activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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