Recombinant Human CCNC, His tagged

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Recombinant Human CCNC, His tagged

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Cat. No. : CCNC-08H
Product overview : The Recombinant Human Cyclin C (1-283aa), His-tagged, fused with 6* his tag, was expressed in E. coli and purified by Ni-sepharose.
Description : CCNC (cyclin C) is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 (CDK8) and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this protein peaks in the G1 phase of the cell cycle. It has been shown that a non-cdk8-associated cellular pool of CCNC combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and that this phosphorylation is required for cells to exit GO efficiently. Other results have shown that a marked elevated immunoreactivity of CCNC was found both in neurons and astrocytes in Alzheimer"s disease (AD). Increased levels of CCNC RNA were detected by ribonuclease protection assay (RPA) in severe AD cases and colocalization of CCNC and its preferred binding partner, CDK8, was only observed in astrocytes but not in neurons.
AA sequence : 1-283aa
Tag : His
Source : E. coli
Species : Human
Purification : Ni-sepharose
Storage buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15% glycerol.
Storage : The protein is stored in PBS buffer at -20°C.Repeated freeze/thaw cycles should be avoided.
Gene Name : CCNC cyclin C[ Homo sapiens ]
Official Symbol : CCNC
Synonyms : CCNC; cyclin C; CycC; OTTHUMP00000016897; hSRB11; SRB11 homolog; cyclin-C
Gene ID : 892
mRNA Refseq : NM_001013399
Protein Refseq : NP_001013417
MIM : 123838
UniProt ID : P24863
Chromosome Location : 6q21
Pathway : Gene Expression
Function : protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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