Recombinant Human CALM1, His-tagged

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Recombinant Human CALM1, His-tagged

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Cat. No. : CALM1-89H
Product Overview : The recombinant human Calmodulin 1 (full-length), fused with an N-terminal His tag, was expressed in E. coli.
Description : Calmodulin 1 is a member of calcium-modulated proteins, which is present in the cytosol and on membranes facing the cytosol, and has a high affinity for calcium. Calmodulin 1 has 4 calcium-binding domains and plays a role in cell growth, cell cycle, signal transduction, and the synthesis and release of neurotransmitters. Calmodulin can bind to the epidermal growth factor receptor at its cytosolic juxtamembrane region and this inhibits its tyrosine kinase activity. A number of other proteins including HSP70 have been shown to interact with Calmodulin 1 in a cell-phase-specific manner.
Source : E. coli
Molecular weight : ~17 kDa
Formulation : Recombinant protein stored in 50 mM sodiumphosphate, pH 7.0, 300 mMNaCl, 150 mM imidazole,0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol.
Stability : The product ships on dry ice and storage at –70 °C is recommended. After opening, aliquot into smaller quantities and store at –70 °C. Avoid repeated handling and multiple freeze/thaw cycles.
Purity : 70–95% as determined by SDS-PAGE.
PDB rendering based on 1a29. :

Gene Name : CALM1 calmodulin 1 (phosphorylase kinase, delta) [ Homo sapiens ]
Official Symbol : CALM1
Synonyms : CALM1; calmodulin 1 (phosphorylase kinase, delta); CAMI; PHKD; DD132; CALML2; calmodulin 1; phosphorylase kinase, delta subunit; EC 2.7.11.19; CALMCAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMIII; CaM
Gene ID : 801
mRNA Refseq : NM_006888
Protein Refseq : NP_008819
MIM : 114180
UniProt ID : P62158
Chromosome Location : 14q24-q31
Pathway : Alzheimer"s disease; Calcium signaling pathway; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term potentiation; Melanogenesis; Neurotrophin signaling pathway; Olfactory transduction; Phosphatidylinositol signaling system; Vascular smooth muscle contraction
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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