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Recombinant Human Cbp/P300-Interacting Transactivator, With Glu/Asp-Rich Carboxy-Terminal Domain, 2, His-tagged

Cat.No.: CITED2-6919H
Product Overview: Recombinant CITED2 protein, fused to His-tagged, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 29.5 kDa.
Description: CITED2 is an important transcriptional cofactor involved in multiple organ development. It is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1a through its competitive binding with HIF-1a to CBP/p300. CITED2 is necessary for mouse fetal liver hematopoiesis and is required for the proper formation of the hyaloid vasculature and for lens morphogenesis.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 50% glycerol, 1mM DTT.
Molecular Mass: 29.5 kDa (278 aa), confirmed by MALDI-TOF.
Protein length: 1-270aa
AA Sequence: MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH
Endotoxin: < 1.0 eu per 1 μg of protein (determined by lal
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 0.25 mg/ml (determined by Bradford assay)
Gene Name: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 [ Homo sapiens ]
Official Symbol: CITED2
Synonyms: CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; cbp/p300-interacting transactivator 2; MRG1; MRG-1; MSG1-related gene 1; MSG-related protein 1; melanocyte-specific gene 1-related gene 1; ASD8; VSD2; P35SRJ;
Gene ID: 10370
mRNA Refseq: NM_001168388
Protein Refseq: NP_001161860
MIM: 602937
UniProt ID: Q99967
Chromosome Location: 6q23.3
Pathway: HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem;
Function: LBD domain binding; RNA polymerase II activating transcription factor binding; SMAD binding; chromatin binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription corepressor activity;

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