Recombinant Human Nth Endonuclease III-Like 1 (E. coli), His-tagged
Cat.No. : | NTHL1-2488H |
Product Overview : | Recombinant human NTHL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 36.6 kDa. |
- Specification
- Gene Information
- Related Products
Description : | NTHL1 is one of the enzyme that has been shown to act on a large number of oxidatively damaged DNA sites. It has an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. It acts on a damaged strand, 5" from the damaged site and incises damaged DNA at cytosines, thymines and guanines. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 0.15M NaCl, 1mM DTT. |
Molecular Mass : | 36.6 kDa (332aa), confirmed by MALDI-TOF. |
Protein length : | 1-312aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MCSPQESGMT ALSARMLTRS RSLGPGAGPR GCREEPGPLR RREAAAEARK SHSPVKRPRK AQRLRVAYEG SDSEKGEGAE PLKVPVWEPQ DWQQQLVNIR AMRNKKDAPV DHLGTEHCYD SSAPPKVRRY QVLLSLMLSS QTKDQVTAGA MQRLRARGLT VDSILQTDDA TLGKLIYPVG FWRSKVKYIK QTSAILQQHY GGDIPASVAE LVALPGVGPK MAHLAMAVAW GTVSGIAVDT HVHRIANRLR WTKKATKSPE ETRAALEEWL PRELWHEING LLVGFGQQTC LPVHPRCHAC LNQALCPAAQ GL |
Purity : | >80% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Gene Name : | NTHL1 nth endonuclease III-like 1 (E. coli) [ Homo sapiens ] |
Official Symbol : | NTHL1 |
Synonyms : | NTHL1; nth endonuclease III-like 1 (E. coli); nth (E.coli endonuclease III) like 1; endonuclease III-like protein 1; NTH1; OCTS3; |
Gene ID : | 4913 |
mRNA Refseq : | NM_002528 |
Protein Refseq : | NP_002519 |
MIM : | 602656 |
UniProt ID : | P78549 |
Chromosome Location : | 16p13.3 |
Pathway : | Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged pyrimidine, organism-specific biosystem; DNA Repair, organism-specific biosystem; |
Function : | 4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; endonuclease activity; hydrolase activity, acting on glycosyl bonds; lyase activity; metal ion binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
Nthl1-4519M | Recombinant Mouse Nthl1 Protein, Myc/DDK-tagged | +Inquiry |
NTHL1-107H | Recombinant Human NTHL1 Protein, His-tagged | +Inquiry |
NTHL1-20H | Recombinant Human NTHL1 protein, MYC/DDK-tagged | +Inquiry |
NTHL1-3545C | Recombinant Chicken NTHL1 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionIndividuals with NTHL1 mutations may benefit from genetic counseling to understand their cancer risks and make informed decisions about their healthcare.
Yes, individuals with NTHL1 mutations may have an increased risk of developing certain types of cancer, making it a potential biomarker for cancer risk assessment.
NTHL1 protein is involved in the base excision repair pathway, where it removes damaged DNA bases and initiates the repair process.
NTHL1 mutations can be inherited in an autosomal recessive manner, meaning that both parents need to carry a mutated copy of the gene to pass it on to their children.
Studies have suggested that individuals of Ashkenazi Jewish descent may have a higher prevalence of NTHL1 mutations and associated cancer risks.
Customer Reviews (3)
Write a reviewWith its well-characterized nature and availability in various formats, the arnC protein is an advantageous tool that aids researchers in achieving their scientific goals.
The manufacturer also ensures that the NTHL1 protein is well-characterized, with extensive documentation on its functional properties.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
Ask a Question for All NTHL1 Products
Required fields are marked with *
My Review for All NTHL1 Products
Required fields are marked with *
Inquiry Basket