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Recombinant Human ADP-Ribosylation Factor-Like 14, His-tagged

Cat.No. : ARL14-2489H
Product Overview : Recombinant human ARL14 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 23.8 kDa.
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  • Gene Information
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Description : ARL14 is a developmentally regulated member of the ADP-ribosylation factor/ARF-like protein family of Ras-related GTPases. MHC class II molecules present peptides to T helper cells to facilitate immune responses and are strongly linked to autoimmune diseases. MHC-II transport was controlled by the GTPase ARL14/ARF7, which recruits the motor myosin 1E via an effector protein ARF7EP.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 40% glycerol, 200mM NaCl, 1mM EDTA.
Molecular Mass : 23.8kDa (212aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher).
Protein length : 1-192aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSLGSKNPQ TKQAQVLLLG LDSAGKSTLL YKLKLAKDIT TIPTIGFNVE MIELERNLSL TVWDVGGQEK MRTVWGCYCE NTDGLVYVVD STDKQRLEES QRQFEHILKN EHIKNVPVVL LANKQDMPGA LTAEDITRMF KVKKLCSDRN WYVQPCCALT GEGLAQGFRK LTGFVKSHMK SRGDTLAFFK QN
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25mg/ml (determined by Bradford assay)
Gene Name : ARL14 ADP-ribosylation factor-like 14 [ Homo sapiens ]
Official Symbol : ARL14
Synonyms : ARL14; ADP-ribosylation factor-like 14; ADP ribosylation factor 7 , ARF7; ADP-ribosylation factor-like protein 14; FLJ22595; ADP-ribosylation factor 7; ARF7;
Gene ID : 80117
mRNA Refseq : NM_025047
Protein Refseq : NP_079323
MIM : 614439
UniProt ID : Q8N4G2
Chromosome Location : 3q25.33
Function : GTP binding; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Are there any ongoing research studies related to ARL14? 08/31/2022

Research is ongoing to uncover the precise cellular roles and mechanisms of ARL14. These studies aim to provide further insights into its functions, interactions, and potential implications in cellular processes and diseases.

Does ARL14 have any role in cancer? 12/18/2021

There is limited information on the potential involvement of ARL14 in cancer. However, some studies have suggested that alterations in ARL14 expression or activity may contribute to tumorigenesis by influencing cellular processes like vesicle trafficking and cell signaling. Further research is needed to fully understand the implications of ARL14 in cancer.

Can ARL14 be used as a biomarker for any diseases? 11/14/2021

Currently, ARL14 is not widely recognized as a specific biomarker for any diseases. However, ongoing research might uncover potential associations between altered ARL14 levels and specific diseases or conditions.

Are there any specific interacting partners of ARL14? 11/23/2020

Several proteins have been identified as potential interacting partners of ARL14, including components of the COPI vesicle coat complex and proteins involved in intracellular vesicle trafficking and membrane remodeling. However, further studies are needed to elucidate the specific protein-protein interactions associated with ARL14.

Are there any known post-translational modifications of ARL14? 04/07/2020

Post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, have been reported for ARL14. These modifications can regulate its activity, subcellular localization, and interaction with other proteins.

Are there any knockout or transgenic animal models for ARL14? 10/07/2019

To date, there are no known reports of knockout or transgenic animal models specifically targeting ARL14. Generating such models could provide valuable insights into the physiological roles of ARL14 and its implications in disease.

Is there any experimental evidence supporting ARL14 involvement in specific cellular pathways? 09/21/2019

While the exact cellular pathways involving ARL14 are still being investigated, studies have suggested its potential involvement in the regulation of intracellular vesicle trafficking, protein secretion, and membrane dynamics. These findings contribute to our understanding of its possible cellular functions.

How does ARL14 contribute to cellular processes like endocytosis and exocytosis? 06/30/2017

While the precise role of ARL14 in endocytosis and exocytosis is not fully understood, studies suggest that it may participate in regulating vesicle trafficking, which is essential for these cellular processes. Further investigations are needed to decipher the specific mechanisms involving ARL14 in these pathways.

Can ARL14 be used as a therapeutic target for neurological disorders? 03/28/2017

Although the exact involvement of ARL14 in neurological disorders is still unclear, some studies suggest its potential association with neurodegenerative diseases. Therefore, further exploration of ARL14's role in the nervous system may identify potential therapeutic avenues for neurological disorders.

Is ARL14 evolutionarily conserved across different species? 09/28/2016

Yes, ARL14 is evolutionarily conserved across various species. It has been identified in both invertebrates and vertebrates, indicating its conserved biological importance throughout evolution.

Are there any diseases or disorders associated with ARL14 mutations? 05/03/2016

Currently, there are no known direct associations between ARL14 mutations and specific diseases or disorders. However, alterations in ARL14 levels or activity may potentially impact cellular processes related to vesicle trafficking and protein secretion, which could contribute to certain pathological conditions.

How does ARL14 compare to other members of the ARL protein family? 03/21/2016

ARL14 shares similarities with other ARL proteins in terms of structure and function. However, it also exhibits distinct features that set it apart from other family members. Comparative studies can help uncover unique aspects of ARL14 and its functional relevance.

Are there any known genetic variations in ARL14? 03/13/2016

Genetic variations, such as single nucleotide polymorphisms (SNPs), have been identified in the ARL14 gene. These variations may impact ARL14 expression or function, potentially influencing cellular processes. The significance and functional consequences of these variations require further investigation.

Can ARL14 be targeted for therapeutic interventions? 03/03/2016

Since the function of ARL14 is not yet fully understood, it is challenging to target it directly for therapeutic interventions. However, by further elucidating its role in cellular processes, it may be possible to develop strategies to modulate its activity indirectly.

Customer Reviews (10)

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Reviews
03/28/2023

    ARL14 protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.

    01/07/2022

      Manufacturers can provide researchers with purified and validated ARL5B protein, ensuring its quality and reliability for use in experiments and trials.

      07/09/2021

        The ARL14 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.

        03/13/2021

          Its purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.

          10/27/2020

            Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.

            09/27/2020

              The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.

              07/29/2020

                They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.

                09/26/2019

                  This can be particularly important in clinical trials to ensure accurate and reliable results.

                  03/14/2019

                    Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the ARL14 protein.

                    03/20/2017

                      If the need arises for larger quantities of ARL14 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.

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