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Recombinant Human RING1 And YY1 Binding Protein, His-tagged

Cat.No.: RYBP-6846H
Product Overview: Recombinant human RYBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Description: RYBP is a member of the polycomb group (PcG). This protein interacts with MDM2 and decreases MDM2-mediated p53 ubiquitination, leading to stabilization of p53 and an increase in p53 activity. RYBP induces cell-cycle arrest and is involved in the p53 response to DNA damage. RYBP has been shown to interact with RING1, YY1, Caspase 10, E2F3, E2F2, Mdm2, Abl gene and CBX2.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20 mM Tris-HCl buffer, pH8.0, 20% glycerol, 1mM DTT, 100mM NaCl.
Molecular Mass: 27.4kDa (252aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
Protein length: 1-228aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMTMGDK KSPTRPKRQA KPAADEGFWD CSVCTFRNSA EAFKCSICDV RKGTSTRKPR INSQLVAQQV AQQYATPPPP KKEKKEKVEK QDKEKPEKDK EISPSVTKKN TNKKTKPKSD ILKDPPSEAN SIQSANATTK TSETNHTSRP RLKNVDRSTA QQLAVTVGNV TVIITDFKEK TRSSSTSSST VTSSAGSEQQ NQSSSGSEST DKGSSRSSTP KGDMSAVNDE SF
Purity: >85% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 0.5mg/ml (determined by Bradford assay)
Gene Name: RYBP RING1 and YY1 binding protein [ Homo sapiens ]
Official Symbol: RYBP
Synonyms: RYBP; RING1 and YY1 binding protein; RING1 and YY1-binding protein; AAP1; apoptin associating protein 1; death effector domain associated factor; DEDAF; ring1 interactor RYBP; YEAF1; YY1 and E4TF1 associated factor 1; APAP-1; DED-associated factor; apoptin-associating protein 1; YY1 and E4TF1-associated factor 1; death effector domain-associated factor;
Gene ID: 23429
mRNA Refseq: NM_012234
Protein Refseq: NP_036366
MIM: 607535
UniProt ID: Q8N488
Chromosome Location: 3p14.2
Pathway: E2F transcription factor network, organism-specific biosystem;
Function: DNA binding; metal ion binding; protein binding; transcription corepressor activity; zinc ion binding;

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